摘要
目的 研究泮托拉唑联合奥曲肽治疗老年消化道出血患者的临床效果。方法 100例老年消化道出血患者,根据治疗方法不同分为对照组(53例)和观察组(47例)。对照组患者采用泮托拉唑进行治疗,观察组患者采用泮托拉唑联合奥曲肽进行治疗。比较两组患者临床疗效、不良反应发生情况及治疗前后生活质量评分。结果 观察组患者治疗总有效率为95.74%,高于对照组的81.13%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为8.51%,与对照组的5.66%比较差异无统计学意义(P>0.05)。治疗后,两组患者生理机能、生理职能、躯体疼痛、一般健康、精力、社会功能、情感职能、精神健康评分均高于本组治疗前,且观察组患者生理机能、生理职能、躯体疼痛、一般健康、精力、社会功能、情感职能、精神健康评分分别为(92.33±3.86)、(91.69±4.27)、(93.06±4.33)、(92.77±4.66)、(92.56±4.01)、(93.16±3.89)、(92.66±2.96)、(93.46±2.57)分,高于对照组的(86.47±3.28)、(85.66±4.89)、(86.36±4.33)、(85.77±3.46)、(86.36±3.26)、(84.58±3.06)、(85.64±3.97)、(86.37±4.04)分,差异具有统计学意义(P<0.05)。结论 老年消化道出血患者采用泮托拉唑联合奥曲肽治疗,可在保证用药安全性的前提下提高临床疗效,改善患者的生活质量,值得临床推荐。
Objective To study the clinical effect of pantoprazole combined with octreotide in the treatment of gastrointestinal bleeding in the elderly.Methods A total of 100 elderly patients with gastrointestinal bleeding were divided into control group(53 cases)and observation group(47 cases)according to different treatment methods.Patients in the control group were treated with pantoprazole,and patients in the observation group were treated with pantoprazole combined with octreotide.The clinical efficacy,occurrence of adverse reactions and quality of life scores before and after treatment were compared between the two groups.Results The total effective rate in the observation group was 95.74%,which was higher than 81.13%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 8.51%,and the difference was not statistically significant compared with 5.66%in the control group(P>0.05).After treatment,the scores of physical functioning,role-function,bodily pain,general health,energy,social functioning,role-emotional and mental health of the two groups were higher than those of this group before treatment;the scores of physical functioning,role-function,bodily pain,general health,energy,social functioning,role-emotional and mental health of the observation group were(92.33±3.86),(91.69±4.27),(93.06±4.33),(92.77±4.66),(92.56±4.01),(93.16±3.89),(92.66±2.96)and(93.46±2.57)points,which were higher than(86.47±3.28),(85.66±4.89),(86.36±4.33),(85.77±3.46),(86.36±3.26),(84.58±3.06),(85.64±3.97)and(86.37±4.04)points of the control group;the differences were all statistically significant(P<0.05).Conclusion Pantoprazole combined with octreotide in the treatment of elderly patients with gastrointestinal bleeding can improve the clinical efficacy and improve the quality of life of patients while ensuring the safety of drug administration,and is worthy of clinical recommendation.
作者
丁月丹
DING Yue-dan(Second People's Hospital of Benxi Manchu Autonomous County,Benxi 117108,China)
出处
《中国实用医药》
2022年第23期133-135,共3页
China Practical Medicine
关键词
泮托拉唑
奥曲肽
老年
消化道出血
不良反应
生活质量
Pantoprazole
Octreotide
Old age
Gastrointestinal bleeding
Adverse reactions
Quality of life
