摘要
目的:探析三种血管活性药物(奥曲肽、生长抑素和垂体后叶素)治疗肝硬化致食管胃底静脉曲张破裂出血的成本-效果,为临床医师选择合理用药方案提供参考。方法:选取2018年7月至2020年12月康平县人民医院诊疗的243例肝硬化致食管胃底静脉曲张破裂出血患者作为研究对象,依据随机数字表法,将研究对象分为A组、B组和C组(每组81例),A组采用垂体后叶素治疗,B组采用奥曲肽治疗,C组采用生长抑素治疗,对比三组的止血有效率、不良反应发生率以及治疗成本,并分析成本-效果比。结果:B组、C组的止血有效率高于A组(P<0.05),但C组患者止血有效率与B组相比,差异不显著(P>0.05)。B组、C组的不良反应发生率均低于A组(P<0.05),但B组、C组患者不良反应发生率对比,差异不明显(P>0.05);C组的治疗成本显著高于A组、B组,且B组的治疗成本高于A组(P<0.05);B组、C组成本-效果比高于A组。结论:三种血管活性药物应用于肝硬化致食管胃底静脉曲张破裂出血患者均可取得一定疗效,垂体后叶素治疗最为经济,但综合成本-效果,奥曲肽、生长抑素治疗方案更佳,具体应用还需遵照患者实际状况而定。
Objective:To explore the cost-effectiveness of three vasoactive drugs(octreotide,somatostatin and pituitrin)in the treatment of esophageal and gastric variceal bleeding caused by liver cirrhosis,so as to provide reference for clinicians to choose rational drug use regimen.Methods:During from July 2018 to December 2020,a total of 243 patients with esophageal and gastric variceal bleeding caused by liver cirrhosis in Kangping People's Hospital were selected as the research subjects.According to the random number table method,the research subjects were divided into three groups:group A,group B and group C(81 cases in each group).Group A was treated with pituitrin,group B was treated with octreotide,and group C was treated with somatostatin.The hemostatic efficiency,incidence of adverse reactions and treatment cost of the three groups were compared,and the cost-effectiveness ratio was analyzed.Results:The hemostatic efficiency of group B and group C was higher than that of group A(P<0.05),but there was no significant difference between group C and group B(P>0.05).The incidence of adverse reactions in group B and group C was lower than that in group A(P<0.05),but there was no significant difference in the incidence of adverse reactions between group B and group C(P>0.05);the treatment cost of group C was significantly higher than that of group A and group B,and the treatment cost of group B was higher than that of group A(P<0.05);the cost-effectiveness ratio of group B and group C was higher than that of group A.Conclusion:Three vasoactive drugs can achieve certain curative effect in patients with esophageal and gastric variceal bleeding caused by liver cirrhosis,pituitrin is the most economical treatment,but the comprehensive cost-effectiveness,octreotide and somatostatin treatment regimen is better,the specific application should be determined according to the actual situation of patients.
作者
于红
Yu Hong(Department of Pharmacy,Kangping People's Hospital,Shenyang Liaoning,110500,China)
出处
《中外女性健康研究》
2022年第16期88-89,182,共3页
Women＇s Health Research
