摘要
目的探讨垂体后叶素联合生长抑素治疗肝硬化上消化道出血的临床疗效。方法选取东方市人民医院2018年8月至2021年8月收治的肝硬化上消化道出血患者120例,按随机数字表法分为观察组和对照组,各60例。两组患者均予常规治疗及注射用生长抑素静脉滴注,观察组患者加予垂体后叶素注射液静脉滴注。两组均连续治疗7 d。结果观察组总有效率为93.33%,显著高于对照组的78.33%(P<0.05)。观察组患者治疗后的D-二聚体、纤维蛋白原水平均显著高于对照组,活化部分凝血活酶时间、凝血酶原时间均显著短于对照组,血管活性肠肽、血管紧张素Ⅱ、血清肾素活性水平均显著低于对照组;免疫球蛋白A、免疫球蛋白E、免疫球蛋白G水平均显著低于对照组(P<0.05)。观察组与对照组不良反应发生率相当(16.67%比11.67%,P>0.05)。结论垂体后叶素联合生长抑素治疗肝硬化上消化道出血,能改善患者的凝血功能,降低炎性因子水平,改善免疫因子水平。
Objective To investigate the clinical efficacy of pituitrin combined with somatostatin in the treatment of uppergastrointestinal hemorrhage due to cirrhosis.Methods A total of 120 patients with upper gastrointestinal hemorrhage due tocirrhosis admitted to the Dongfang People’s Hospital from August 2018 to August 2021 were selected and divided into theobservation group and the control group according to the random number table method,with 60 cases in each group.The patientsin the two groups were given routine treatment and intravenous infusion of Somatostatin for Injection,on this basis,the patients inthe observation group were given the intravenous drip of Pituitrin Injection.Both groups were treated continuously for 7 d.Results Thetotal effective rate in the observation group was 93.33%,which was significantly higher than 78.33%in the control group(P<0.05).After treatment,the levels of D-dimer(D-D)and fibrinogen(Fib)in the observation group were significantly higher than thosein the control group,while the activated partial thromboplastin time(APTT)and prothrombin time(PT)in the observation groupwere significantly shorter than those in the control group(P<0.05).The levels of vasoactive intestinal peptide(VIP),angiotensinⅡ(AngⅡ)and plasma renin activity(PRA)in the observation group were significantly lower than those in the control group,andthe levels of immunoglobulin A(Ig A),immunoglobulin E(Ig E)and immunoglobulin G(Ig G)in the observation group weresignificantly lower than those in the control group(P<0.05).The incidence of adverse drug reactions in the observation groupwas similar to that in the control group(16.67%vs.11.67%,P>0.05).Conclusion Pituitrin combined with somatostatin in thetreatment of upper gastrointestinal hemorrhage due to cirrhosis can improve the coagulation function,reduce the levels ofinflammatory factors and improve the levels of immune factors.
作者
王秀辉
伍志
庄增礼
李伟
WANG Xiuhui;WU Zhi;ZHUANG Zengli;LI Wei(Dongfang People's Hospital,Dongfang,Hainan,China 572600;Wanning People's Hospital,Wanning,Hainan,China 571500)
出处
《中国药业》
CAS
2022年第20期101-104,共4页
China Pharmaceuticals
基金
海南省卫生计生行业科研项目[19A200100]。
关键词
肝硬化上消化道出血
垂体后叶素
生长抑素
临床疗效
炎性因子
免疫因子
upper gastrointestinal hemorrhage due to cirrhosis
pituitrin
somatostatin
clinical efficacy
inflammatory factors
immune factors
