摘要
目的 探究急性进展性脑梗死患者行氯吡格雷联合阿司匹林治疗的临床效果。方法 82例急性进展性脑梗死患者,随机分为实验组及对照组,每组41例。实验组应用氯吡格雷联合阿司匹林治疗,对照组应用阿司匹林治疗。比较两组临床疗效,治疗前后的血浆粘度、全血低切粘度、纤维蛋白原、美国国立卫生研究院卒中量表(NIHSS)评分,不良反应发生情况,治疗后的生活质量评分。结果 实验组总有效率97.56%高于对照组的82.93%,差异具有统计学意义(P<0.05)。治疗后,实验组血浆粘度为(1.32±0.11)mPa·s、全血低切粘度为(9.02±1.45)mPa·s、纤维蛋白原为(3.94±0.02)g/L、NIHSS评分为(8.64±2.57)分,均低于对照组的(1.87±0.23)mPa·s、(9.88±1.69)mPa·s、(4.15±0.02)g/L、(11.69±2.45)分,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。实验组的心理功能评分为(86.23±4.17)分、社会功能评分为(87.76±4.61)分、躯体功能评分为(83.23±5.18)分,均高于对照组的(75.21±5.12)、(75.27±5.61)、(73.42±5.58)分,差异具有统计学意义(P<0.05)。结论 临床治疗急性进展性脑梗死患者联用氯吡格雷与阿司匹林可使其血液粘度改善,缓解神经功能缺损程度,不良反应少,有利于患者生活质量水平的提高,值得推广。
Objective To investigate the clinical effect of clopidogrel combined with aspirin in patients with acute progressive cerebral infarction.Methods A total of 82 patients with acute progressive cerebral infarction were randomly divided into experimental group and control group,with 41 cases in each group.The experimental group was treated with clopidogrel combined with aspirin,and the control group was treated with aspirin.Both groups were compared in terms of clinical efficacy,plasma viscosity,whole blood low-shear viscosity,fibrinogen,National Institutes of Health stroke scale(NIHSS)score before and after treatment,occurrence of adverse reactions,and quality of life scores after treatment.Results The total effective rate 97.56%of the experimental group was higher than 82.93%of the control group,and the difference was statistically significant(P<0.05).After treatment,the plasma viscosity of the experimental group was(1.32±0.11)mPa·s,the whole blood low-shear viscosity was(9.02±1.45)mPa·s,the fibrinogen was(3.94±0.02)g/L,and the NIHSS score was(8.64±2.57)points,which were lower than(1.87±0.23)mPa·s,(9.88±1.69)mPa·s,(4.15±0.02)g/L,and(11.69±2.45)points of the control group,and the differences were all statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The psychological function score of the experimental group was(86.23±4.17)points,the social function score was(87.76±4.61)points,and the physical function score was(83.23±5.18)points,which were higher than(75.21±5.12),(75.27±5.61),and(73.42±5.58)points of the control group,and the differences were all statistically significant(P<0.05).Conclusion In the clinical treatment of patients with acute progressive cerebral infarction,clopidogrel combined with aspirin can improve the blood viscosity,relieve the degree of neurological deficit with less adverse reactions,and improve the quality of life of patients,which is worthy of promotion.
作者
单秀艳
SHAN Xiu-yan(Yingkou Central Hospital,Yingkou 115000,China)
出处
《中国现代药物应用》
2022年第19期87-90,共4页
Chinese Journal of Modern Drug Application
关键词
急性进展性脑梗死
氯吡格雷
阿司匹林
临床效果
Acute progressive cerebral infarction
Clopidogrel
Aspirin
Clinical effect
