摘要
目的探讨替罗非班对进展性脑梗死患者神经功能及血小板功能的影响。方法选择2019年3月至2021年4月吴川市人民医院收治的进展性脑梗死患者88例,根据随机数字表分为两组,各44例。两组患者入院后均予以基础治疗,在此基础上,对照组口服阿司匹林、硫酸氢氯吡格雷治疗,研究组在对照组基础上予以替罗非班治疗,两组均连续治疗2周。观察两组神经功能、血小板功能[血小板黏附率(PAdT)、血小板聚集率(PAgT)]及血清炎性因子[白介素-8(IL-8)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)]水平。结果治疗2周后,两组NIHSS评分均下降,且研究组NIHSS评分更低,差异有统计学意义(P<0.05);治疗2周后,两组PAgT、PAdT水平均下降,且研究组PAgT、PAdT水平更低,差异有统计学意义(P<0.05);治疗2周后,两组血清IL-8、hs-CRP、IL-6水平均下降,且研究组IL-8、hs-CRP、IL-6水平更低,差异有统计学意义(P<0.05)。两组不良事件发生率比较,差异无统计学意义(P>0.05)。结论进展性脑梗死患者采用替罗非班治疗可有效改善神经功能与血小板功能,降低血清炎症因子水平,不会增加不良事件发生率,安全性较高。
Objective To investigate the effect of tirofiban on the nerve function and platelet function in patients with progressive cerebral infarction.Methods 88 patients with progressive cerebral infarction admitted to the People’s Hospital of Wuchuan from March 2019 to April 2021 were divided into two groupsaccording to the randomized number table method,with 44 cases in each group.Both groups were given basic treatment after admission.Furthermore,the control group was treated with aspirin and clopidogrel sulfate,and the study group was treated with tirofiban on the basis of the control group.Both groups were treated continuously for 2 weeks.Nerve function,platelet function[platelet adhesion rate(PAdT),platelet aggregation rate(PAg T)]levels of serum inflammatory factors[interleukin-8(IL-8),hypers C reactive protein(hs-CRP),interleukin-6(IL-6)]levels between two groups were observed and compared.Results After 2 weeks of treatment,NIHSS scores were lower in both groups,and NIHSS score of the study group was lower,the difference was statistically significant(P<0.05).After 2 weeks of treatment,PAgT,PAdT levelsdecreased in both groups,and the PAgT,PAdT of the study group was lower,and the difference was statisticallysignificant(P<0.05).Serum IL-8,hs-CRP,IL-6 levels decreased in both group too.IL-8,the hs-CRP、IL-6 level of the study groupwere lower,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion Tirofiban therapy in patients with progressive cerebral infarction can effectively improve nerve function and platelet function,reduce serum inflammatory factor levels,and will not increase the incidence of adverse events,and the safety is high.
作者
陈观荣
洗飞
黄宇
李波
CHEN Guanrong;XIAN Fei;HUANG Yu;LI Bo(Department of Neurology,The People's Hospital of Wuchuan,Guangdong,Wuchuan,524500,china)
出处
《新疆医学》
2022年第9期1057-1059,共3页
Xinjiang Medical Journal
关键词
进展性脑梗死
替罗非班
神经功能
血小板功能
Progressive cerebral infarction
Tirofiban
Neurological function
Platelet function
