摘要
目的探讨虎地肠溶胶囊联合美沙拉嗪肠溶片治疗溃疡性结肠炎的临床疗效及对患者中医证候积分、肠道黏膜屏障功能及Th1/Th2、Th17/Treg细胞失衡的影响。方法选择2020年4月—2021年4月于本院就诊的102例溃疡性结肠炎患者作为研究对象,随机分为对照组和治疗组两组,每组各51例。对照组口服美沙拉嗪肠溶片(4片/次,4次/d);在对照组治疗的基础上,治疗组口服虎地肠溶胶囊(4粒/次,3次/d)。两组共计治疗12周。比较两组患者的临床疗效、中医证候积分、肠道黏膜屏障功能、炎症因子水平及不良反应发生率。结果治疗后,对照组和治疗组总有效率分别为82.35%和96.08%,与对照组相比,治疗组总有效率明显升高,差异有统计学意义(P<005)。治疗后,两组中医证候积分、二胺氧化酶、D-乳酸水平均较治疗前降低,差异有统计学意义(P<005);且治疗组中医证候积分、二胺氧化酶、D-乳酸水平较对照组低,差异有统计学意义(P<005)。治疗后,两组IFN-g和IL-17表达水平较治疗前明显降低,而IL-4和TGF-b表达水平显著升高,差异均有统计学意义(P<005);且治疗组IFN-g和IL-17表达水平较对照组低,IL-4和TGF-b表达水平较对照组高,差异均有统计学意义(P<005)。治疗后两组不良反应发生率比较,差异无统计学意义(P=0.650)。结论虎地肠溶胶囊联合美沙拉嗪肠溶片治疗溃疡性结肠炎有助于改善患者临床不适症状和肠道黏膜屏障功能,在机制上可能与改善Th1/Th2、Th17/Treg细胞失衡有关。
Objective To investigate the clinical efficacy of Hudi enteric-coated capsules combined with mesalazine in the treatment of ulcerative colitis,and its effect on TCM syndrome scores,intestinal mucosal barrier function and imbalance of Th1/Th2 and Th17/Treg cells after treatment were also investigated.Methods A total of 102 patients suffered with ulcerative colitis those were admitted to our hospital between April 2020 and April 2021 were enrolled as study subjects,and they were randomly divided into control group and treatment group,with 51 cases in each group.Patients in the control group were orally administered with Mesalazine,4 pills/time,4 times/day.Patients in the treatment group were orally administered with Hudi enteric-coated capsules,4 capsules/time,3 times/day on the basis of the control group.The two groups of patients were treated for 12 weeks.The differences in clinical efficacy,TCM syndrome scores,intestinal mucosal barrier function,levels of inflammatory factors and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rates in the control group and the treatment group were 82.35%and 96.08%,respectively.The total effective rate in the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the TCM syndrome scores,the levels of diamine oxidase and D-lactic acid in the two groups were significantly decreased(P<0.05).Compared with control group,the TCM syndrome scores and the levels of diamine oxidase,D-lactic acid were significantly decreased in the treatment group(P<0.05).After treatment,the expression levels of IFN-g and IL-17 in the two groups were significantly decreased(P<0.05),while the levels of IL-4 and TGF-b were significantly increased(P<0.05).Compared with control group,the expression levels of IFN-g and IL-17 in the treatment group were significantly decreased(P<0.05),while the levels of IL-4 and TGF-b were significantly increased(P<0.05).There was no significant difference in the incidence o
作者
杨晓庆
张俊
黄振
李道宽
Yang Xiaoqing;Zhang Jun;Huang Zhen;Li Daokuan(Department of liver,gallbladder,spleen and stomach,Zhumadian hospital of traditional Chinese medicine,Zhumadian,Henan,463000,China)
出处
《齐齐哈尔医学院学报》
2022年第16期1555-1558,共4页
Journal of Qiqihar Medical University
