摘要
目的 探讨同型半胱氨酸和血糖联合检测与脑卒中患病风险的相关性,为脑卒中的早期防治提供循证依据。方法 采用回顾性调查研究方法,选择2007年1月至2012年12月解放军总医院确诊的1 364例脑卒中住院患者为观察组,按年龄、性别、体质量指数(BMI)进行11配对选择同期在本院住院治疗的1 364例单纯腰椎间盘突患者为对照组。通过医疗记录收集2组患者的年龄、性别、病史、家族病史、身高、体质量、血压、血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、同型半胱氨酸和空腹血糖水平等临床特征资料。采用配对χ^(2)检验(McNemar检验)、连续变量的配对t检验和Wilcoxon配对符号秩和检验等比较2组患者各类指标的差异,采用配对logistic回归模型分析方法分析脑卒中患病风险因素。结果 观察组与对照组患者的年龄、性别、BMI及高脂血症家族史比较差异无统计学意义(P>0.05),观察组患者中吸烟、饮酒者占比和有高血压、脑卒中、冠状动脉性心脏病(CAHD)、糖尿病等家族史者占比、有高血压、脑卒中、CAHD、高脂血症、糖尿病既往史者占比以及目前有高血压、血脂异常、血糖以及同型半胱氨酸水平增高者占比均显著高于对照组(P<0.05)。调整吸烟情况、饮酒史、家族史(高血压、脑卒中、CAHD、高脂血症、糖尿病)、既往史(高血压、脑卒中、CAHD、高脂血症、糖尿病)、是否患有高血压以及血脂异常因素后,空腹血糖水平增高、同型半胱氨酸水平增高与脑卒中的发生相关(P<0.05)。与血糖正常的患者相比较,高血糖患者发生脑卒中的风险增加74.7%(P<0.05);与正常水平同型半胱氨酸患者相比较,高同型半胱氨酸患者发生脑卒中的风险增加47.4%(P<0.05)。调整吸烟情况、饮酒史、家族史(高血压、脑卒中、CAHD、高脂血症、糖尿病)、既往史(高血压、脑卒中、CAHD�
Objective To investigate the correlation between the combine detection of homocysteine and blood glucose and the risk of stroke, and provide evidence based basis for the prevention and treatment of stroke.Methods A retrospective study design was used.A total of 1 364 stroke patients diagnosed in Chinese PLA General Hospital from January 2007 to December 2012 were selected as the observation group, and 1 364 patients with simple prolapse of lumbar intervertebral disc whose age, gender and body mass index(BMI) were matched with the patients in the observation group(1:1) were recruited as the control group.The age, sex, medical history, family history, height, body mass, blood pressure, total serum cholesterol, triacylglycerol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, homocysteine and fasting blood glucose level of the patients in the two groups were collected.The differences of various indicators of patients between the two groups were compared by the paired χ^(2) test(McNemar test),paired t test of continuous variables and Wilcoxon paired sign rank sum test, and the risk factors of stroke was analyzed by the paired logistic regression model.Results There was no significant difference in age, sex, BMI and family history of hyperlipidemia of patients between the observation group and the control group(P>0.05).The percentage of smokers and drinkers, the percentage of patients with family history of hypertension, stroke, coronary atery heart disease(CAHD),diabetes, the percentage of patients with previous history of hypertension, stroke, CAHD,hyperlipidemia, diabetes, and the percentage of patients with hypertension, dyslipidemia, increased blood glucose and increased homocysteine of patients in the observation group were significantly higher than those in the control group(P<0.05).The high fasting blood glucose and homocysteine level were associated with the occurrence of stroke after adjusting for smoking status, drinking, family history(hypertension, stroke, CAHD,hyperlipidemia, d
作者
梁书锋
栾恒钰
宋玉健
宋丽莎
李世铭
刘飞翔
戴锦杰
孙媛媛
陈巧
晏黎
卢楠
衣志勇
赛晓勇
LIANG Shufeng;LUAN Hengyu;SONG Yujian;SONG Lisha;LI Shiming;LIU Feixiang;DAI Jinjie;SUN Yuanyuan;CHEN Qiao;YAN Li;LU Nan;YI Zhiyong;SAI Xiaoyong(Department of Epidemiology and Statistics,the Graduate School of the Chinese PLA General Hospital,Beijing 100853,China;Health Care Division,Security Bureau of Headquarters of the General Staff,Beijing 100017,China)
出处
《新乡医学院学报》
CAS
2022年第10期972-977,共6页
Journal of Xinxiang Medical University
基金
中央保健专项科研课题(编号:12BJZ27)。
