摘要
目的:探讨纤维蛋白原与凝血酶原复合物联合应用对妇产科大出血患者的影响。方法:回顾性分析2019年2月-2021年10月孝感市第一人民医院收治的90例妇产科大出血患者的临床资料,根据治疗方式的不同,将其分为观察组与对照组,各45例,其中对照组的治疗方案为输注凝血酶原复合物,观察组为纤维蛋白原与凝血酶原复合物联合输注,观察治疗后两组的凝血指标变化、再次手术率、治疗有效率、出血量及治疗前后的纤维蛋白原水平。结果:治疗后,两组的凝血指标均下降,且观察组各项凝血指标均较对照组低(P<0.05)。治疗后,观察组的再次手术率为2.22%,低于对照组的13.33%(P<0.05);治疗有效率为97.78%,高于对照组的82.22%(P<0.05)。治疗后,观察组10 min、1 h及2 h出血量均低于对照组(P<0.05)。治疗后1、3、7 d,观察组的纤维蛋白原水平均较对照组高(P<0.05)。结论:给予妇产科大出血患者纤维蛋白原与凝血酶原复合物联合输注治疗,其可有效地改善患者出血状况及凝血指标,提高患者纤维蛋白原水平,降低出血量及再次手术率,确保临床治疗效果。
Objective:To investigate the effect of combined application of fibrinogen and prothrombin complex on patients with massive hemorrhage in obstetrics and gynecology.Method:The clinical data of 90 patients with major bleeding in obstetrics and gynecology admitted to Xiaogan First People’s Hospital from February 2019 to October 2021 were retrospectively analyzed.According to the different treatment methods,they were divided into observation group and control group,45 cases in each group.The treatment regimen for the control group was infusion of Prothrombin Complex.The observation group was combined infusion of Fibrinogen and Prothrombin Complex.After treatment,the changes of coagulation indexes,reoperation rate,effective rate,blood loss and fibrinogen level before and after treatment were observed between the two groups.Result:After treatment,the coagulation indexes in both groups decreased,and the coagulation indexes in the observation group were lower than those in the control group(P<0.05).After treatment,the reoperation rate in the observation group was 2.22%,which was lower than 13.33%in the control group(P<0.05),the effective rate of observation group was 97.78%,which was higher than 82.22%in the control group(P<0.05).After treatment,the intraoperative blood loss in the observation group at 10 min,1 hour and 2 hours were lower than those in the control group(P<0.05),at 1,3 and 7 days after treatment,the fibrinogen level in observation group were higher than those in the control group(P<0.05).Conclusion:Combined infusion of Fibrinogen and Prothrombin Complex was given to patients with major bleeding in gynecology and obstetrics,it can effectively improve the patient’s bleeding status and coagulation indicators,improve the fibrinogen level of patients,reduce the amount of bleeding and the rate of reoperation,ensure the clinical treatment effect.
作者
邹婧
ZOU Jing(Xiaogan First People’s Hospital,Xiaogan 432000,China)
出处
《中外医学研究》
2022年第25期37-41,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
纤维蛋白原
凝血酶原复合物
妇产科大出血
凝血指标
Fibrinogen
Prothrombin Complex
Major bleeding in gynecology and obstetrics
Blood coagulation indexes
