摘要
目的:探究交叉配型与血小板抗体检测在血小板输注治疗患者中的应用价值。方法:选取2019年1月-2020年1月在本院多次接受输注血小板治疗的血液病患者74例,依据随机数表法分为对照组与观察组,各37例。对照组行随机血小板输注,观察组交叉配型与血小板抗体检测后选择相容血小板输注。对比两组的血小板输注有效率,计算1h、24h血小板纠正指数(CCI),并对凝血功能进行评价。结果:74例患者中,抗体阳性患者40例(54.05%),随着血小板输注次数增加,抗体阳性率逐渐升高,且差异具有统计学意义(P<0.05)。观察组血小板输注有效率(75.68%)明显高于对照组(18.92%),且差异有统计学意义(P<0.05)。观察组血小板输注18h及24h时的CCI均明显高于对照组,且差异有统计学意义(P<0.05)。观察组输血后的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)及凝血酶时间(TT)均明显低于对照组,且差异有统计学意义(P<0.05)。结论:在输血前对血小板输注治疗患者使用交叉配型与血小板抗体检测,血小板输注效果显著,可纠正血小板计数并改善患者的凝血功能。
Objective:To explore the application value of cross-matching and platelet antibody detection in patients receiving platelet transfusion.Methods:A total of 74 patients with blood diseases who received multiple platelet transfusion in the hospital from January 2019 to January 2020 were enrolled and divided into control group and observation group by random number table method,37 cases in each group.The control group received random platelet transfusion,while observation group received compatible platelet transfusion after crossmatching and platelet antibody detection.The response rate of platelet transfusion was compared between the two groups.The corrected count increment(CCI)at 1h and 24h after platelet transfusion was calculated,and coagulation function was evaluated.Results:Antibody detection results showed that there were 40 antibody positive cases(54.05%).With the increase of platelet transfusion times,the antibody positive rate increased,and the difference was statistically significant(PV0.05).The response rate of platelet transfusion in observation group(75.68%)was higher than that in control group(18.92%),and the difference was statistically significant(P<0.05).CCI values at 1 h and 24 h after platelet transfusion in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).After transfusion,activated partial thromboplastin time(APTT),prothrombin time(PT)and thrombin time(TT)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).ConClusion:The application of cross-matching and platelet antibody detection before transfusion in patients with undergoing platelet transfusion can improve the platelet transfusion effect,correct platelet count and improve their coagulation function.
作者
刘丰
LIU Feng(Department of Clinical Laboratory Medicine,Shangqiu Blood Center,Henan Shangqiu 476000)
出处
《医学检验与临床》
2022年第9期27-29,48,共4页
Medical Laboratory Science and Clinics
关键词
血小板输注
交叉配型
血小板抗体检测
血液病
Platelet transfusion
Cross-matching
Platelet antibody detection
Blood disease
