摘要
目的 分析麦角新碱与缩宫素治疗产后出血的临床效果及对凝血功能的影响。方法 回顾性选取徐州市贾汪区人民医院2019年1月—2021年11月收治90例产后出血产妇作为研究对象,根据其不同治疗方案分组,将采用缩宫素治疗患者纳入参照组(45例),将采用马来酸麦角新碱联合缩宫素治疗患者纳入研究组(45例),比较两组产妇不同时间点出血量和产前、产后24 h的血红蛋白(Hb)、脑钠肽(BNP)、凝血功能指标,并观察和对比两组产妇不良反应发生率。结果 研究组产后30 min出血量(185.26±26.64)mL、产后1 h出血量(226.41±18.47)mL、产后2 h出血量(306.19±22.33)mL、产后24 h出血量(318.52±36.16)mL均显著少于参照组,差异有统计学意义(t=6.510、13.063、12.235、10.792,P<0.05);产后24 h,研究组Hb水平(7.36±0.93)g/L高于参照组,BNP水平(35.48±2.25)pg/mL低于参照组,差异有统计学意义(t=13.162、15.149,P<0.05);产后24 h,研究组PT(10.79±1.45)s、APTT(29.63±2.12)s、TT(13.15±1.36)s均短于参照组,FIB水平(3.11±0.24)g/L低于参照组,差异有统计学意义(t=6.819、6.877、7.437、11.744,P<0.05);两组产妇不良反应发生率分别为11.11%和15.56%,差异无统计学意义(χ^(2)=0.385,P>0.05)。结论 采用麦角新碱联合缩宫素治疗产后出血可有效减少产妇产后出血量,减轻产妇产后血液流失和血容量的降低,改善凝血功能。
Objective To analyze the clinical effect of ergometrine and oxytocin in the treatment of postpartum hemorrhage and their effect on coagulation function.Methods A total of 90 cases of postpartum hemorrhage patients admitted to the People’s Hospital of Jiawang District, Xuzhou City from January 2019 to November 2021 were retrospectively selected as the research subjects. According to their different treatment regimens, the patients treated with oxytocin were included in the reference group(45 cases), and the patients treated with ergometrine maleate combined with oxytocin were included in the research group(45 cases). The blood loss and hemoglobin(Hb), brain natriuretic peptide(BNP) and coagulation function indexes before and after delivery were compared between the two groups at different time points. The incidence of adverse reactions of puerperae in the two groups was observed and compared.Results The bleeding volume at 30 minutes postpartum was(185.26±26.64) mL, the volume of bleeding at 1 hour postpartum was(226.41±18.47) mL, the volume of bleeding at 2 hours postpartum was(306.19±22.33) mL, and the volume of bleeding at 24 hours postpartum was(318.52±36.16) mL, significantly less than the reference group. The difference was statistically significant(t=6.510, 13.063, 12.235, 10.792, P<0.05). At 24 h postpartum, the Hb level in the study group(7.36±0.93) g/L was higher than reference group, and the BNP level(35.48±2.25) pg/mL were lower than reference group, and the difference was statistically significant(t=13.162, 15.149, P<0.05). At 24 h postpartum, the PT(10.79±1.45)s, APTT(29.63±2.12)s, and TT(13.15±1.36)s of the study group were all shorter than those of the reference group, and the level of FIB(3.11±0.24) g/L was lower than that of the reference group. The difference was statistically significant(t=6.819, 6.877, 7.437, 11.744, P<0.05). The incidences of maternal adverse reactions in the two groups were 11.11% and 15.56%, respectively, and the difference was not statistically significant(χ^(2
作者
苏平
SU Ping(Department of Obstetrics and Gynecology,People's Hospital of Jiawang District,Xuzhou,Jiangsu Province,221000 China)
出处
《系统医学》
2022年第16期182-185,190,共5页
Systems Medicine
关键词
麦角新碱
缩宫素
产后出血
凝血功能
Ergometrine
Oxytocin
Postpartum hemorrhage
Coagulation function
