摘要
目的了解2015—2020年杭州市新生儿隐睾症(cryptorchidism)发病率与母体预产年龄和居住地的相关性,为临床预防和治疗隐睾症提供科学依据。方法采用描述性分析方法,对671605例来自杭州市2014年10月至2020年9月产前筛查的孕妇及其新生儿出生缺陷监测随访资料进行分析。比较不同预产年龄、不同居住城区的孕妇,其妊娠结局为隐睾症的新生儿发病率是否存在差异。结果在671605例孕妇中共随访到确诊的隐睾症新生儿112例,其发病率为1.67/万。从2015年的0.39/万,上升到2020年的2.47/万(P<0.001)。郊区隐睾症发病率高于主城区和远郊(2.47/万vs1.31/万、0.87/万),不同城区间隐睾症发病率差异有统计学意义(P<0.001)。孕妇年龄<25岁组的隐睾症发病率最低(1.35万),≥40岁组最高(9.26/万)。各年龄组间隐睾症发病率差异均有统计学意义(P<0.001)。高龄孕妇子代发生隐睾症的危险因素是低龄孕妇的2.45倍。结论中国杭州市新生儿隐睾症的发病率为1.67/万,有逐年增高趋势,郊区隐睾症发病率高于主城区和远郊。子代隐睾症发病率与母亲的预产年龄有关,产妇的预产年龄越大,隐睾症的发病率越高,高龄孕妇子代发生隐睾症的危险因素是低龄孕妇的2.45倍。
Objective This study aims to analyze the correlation between the incidence of neonatal cryptorchidism and maternal age and residence in Hangzhou from 2015 to 2020 in order to provide scientific evidence for clinical prevention and treatment of cryptorchidism.Methods Surveillance data for birth defects of Hangzhou were analyzed retrospectively.The incidence of neonatal cryptorchidism was compared among different maternal ages and different residence.Results There were 112 cases of cryptorchidism among 671605 pregnancies,and the cryptorchidism incidence was 1.67 per 10000 births.The incidence of cryptorchidism increased from 0.39 per 10000 births in 2015 to 2.47 per 10000 births in 2020(P<0.001).Cryptorchidism’s incidence rates in suburban areas were higher than that in counties and main urban areas,which were 2.47/10000,1.31/10000 and 0.87/10000,respectively,and they had significant difference(P<0.001).Maternal age<25 years had the lowest cryptorchidism incidence(1.35/million),as≥40 years had the highest one(9.26/million),and the difference was statistically significant(P<0.001).The risk factors of cryptorchidism in the offspring of elderly pregnant women were 2.45 times higher than that of young pregnant women.Conclusion The incidence of cryptorchidism in Hangzhou was 1.67 per 10000 births,with a yearly increasing trend.On the one hand,the incidence of cryptorchidism in the suburban areas was higher than that in counties and main urban areas.On the other hand,maternal age also played a role,specifically,the older the maternal age,the higher the incidence of cryptorchidism.Moreover,the risk factors of cryptorchidism in the offspring of elderly pregnant women were 2.45 times higher than that of young pregnant women.
作者
张慧敏
陈益明
张闻
宁雯雯
陈怡洁
ZHANG Huimin;CHEN Yiming;ZHANG Wen;NING Wenwen;CHEN Yijie(The Fourth School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053,China;Department of Prenatal Diagnosis(Screening)Centre,Hangzhou Women’s Hospital,Hangzhou Maternal and Child Health Hospital,Hangzhou,Zhejiang 310008,China)
出处
《中国优生与遗传杂志》
2022年第8期1467-1471,共5页
Chinese Journal of Birth Health & Heredity
关键词
隐睾症
发病率
流行病学
孕妇年龄
城区分布
cryptorchidism
incidence
epidemiological study
maternal age
urban distribution
