摘要
目的:探讨鼻窦炎鼻内镜术后丙酸氟替卡松喷雾剂结合鼻腔冲洗治疗的临床效果。方法:回顾性选取2020年2月—2021年2月本院鼻窦炎患者100例,依据鼻内镜术后治疗方法分为丙酸氟替卡松喷雾剂结合鼻腔冲洗治疗组(结合治疗组)、丙酸氟替卡松喷雾剂单独治疗组(单独治疗组)两组,各50例,比较两组主要症状评分、鼻腔鼻窦结局、血清炎症因子水平、鼻内镜检查结果、临床疗效、鼻腔黏膜上皮化时间、住院时间、复发情况。结果:结合治疗组打喷嚏、脓性鼻涕、鼻涕倒流、需擤鼻涕、头晕评分、SNOT-20评分均低于单独治疗组,差异有统计学意义(P<0.05);结合治疗组血清IL-2、IL-4、IL-6、CRP水平均低于单独治疗组,差异有统计学意义(P<0.05);结合治疗组鼻内镜检查症状存在率为4.00%,低于单独治疗组的20.00%,差异有统计学意义(P<0.05);结合治疗组治疗的总有效率为98.00%,高于单独治疗组的84.00%,差异有统计学意义(P<0.05);结合治疗组鼻腔黏膜上皮化时间、住院时间短于单独治疗组,复发率低于单独治疗组,差异有统计学意义(P<0.05)。结论:鼻内镜术后鼻腔冲洗结合丙酸氟替卡松喷雾剂治疗鼻窦炎的临床效果显著,可有效改善患者临床症状及鼻腔鼻窦结局,减轻患者炎症反应,缩短患者鼻腔黏膜上皮化时间、住院时间,降低患者复发率。
Objective:To investigate the clinical effect of fluticasone propionate spray combined with nasal irrigation after sinusitis endoscopic sinus surgery.Methods:A total of 100 patients with sinusitis in our hospital from February 2020to February 2021 were retrospectively selected.According to the treatment methods after endoscopic sinus surgery,they were divided into Fluticasone Propionate Spray combined with nasal irrigation treatment group(combined treatment group)and Fluticasone Propionate Spray alone treatment group(single treatment group),with 50 cases in each group.The main symptom score,nasal sinus outcome,serum inflammatory factor level,endoscopic examination results,clinical efficacy,nasal mucosal epithelialization time,hospitalization time and recurrence were compared between the two groups.Results:The scores of sneezing,purulent nasal discharge,nasal discharge,need to blow,dizziness and SNOT-20 in the combined treatment group were lower than those in the single treatment group,and the difference was statistically significant(P<0.05).The levels of serum IL-2,IL-4,IL-6 and CRP in the combined treatment group were lower than those in the single treatment group,and the difference was statistically significant(P<0.05).The presence rate of nasal endoscopy symptoms in the combined treatment group was 4.00%,which was lower than 20.00%in the single treatment group,and the difference was statistically significant(P<0.05).The total effective rate of the combined treatment group was 98.00%,which was higher than 84.00%of the single treatment group,and the difference was statistically significant(P<0.05).The time of nasal mucosa epithelization and hospitalization in the combined treatment group were shorter than those in the single treatment group,and the recurrence rate was lower than that in the single treatment group,the difference was statistically significant(P<0.05).Conclusion:Nasal irrigation combined with fluticasone propionate spray after endoscopic sinus surgery has significant clinical effect in the treatment
作者
杨文华
姚辉
刘强
YANG Wenhua;YAO Hui;LIU Qiang(Department of Otolaryngology,Tianjin Beichen Hospital,Tianjin 300400,China;Department of Traditional Chinese Medicine,Tianjin Beichen Hospital,Tianjin 300400,China)
出处
《中国药物滥用防治杂志》
CAS
2022年第8期1084-1088,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
鼻窦炎
鼻内镜术
丙酸氟替卡松喷雾剂
鼻腔冲洗
鼻腔鼻窦结局
炎症因子
复发
Sinusitis
Nasal endoscopy
Fluticasone propionate spray
Nasal irrigation
Nasal cavity and paranasal sinus outcome
Inflammatory factors
Recrudescence
