摘要
目的通过对接受ART和未接受ART的HIV/AIDS合并神经梅毒患者的一般情况及脑脊液检测指标进行对比观察研究,探讨ART对神经梅毒脑脊液检测指标的影响。方法将2014年1月至2021年10月于首都医科大学附属北京地坛医院住院的HIV/AIDS合并神经梅毒患者,按是否ART分为ART组和非ART组。对两组患者血清及脑脊液(CSF)检测指标进行对比分析。结果入组58例患者,其中ART组20例,非ART组38例,均为男性,中位年龄33岁。非ART组有症状患者比例(78.9%)、CD4细胞计数<200个/μL患者比例(68.4%)、合并机会性感染(OI)患者比例(52.6%)均高于ART组(25.0%,35.0%,10.0%),驱梅治疗患者比例(15.8%)低于ART组(90.0%)。在血清及脑脊液检查中,非ART组CSF-TRUST阳性率(73.7%)、CSF蛋白含量异常率(84.2%)、白细胞计数(35个/μL)及蛋白含量值(87.0 mg/dL)均高于ART组(35.0%,45.0%,14个/μL,41.0 mg/dL),差异均有统计学意义。结论ART可对HIV/AIDS合并神经梅毒患者实验室检测指标产生一定影响进而增加此类患者的诊断难度。
Objective To investigate ART’s influence on neurosyphilis by comparing the serum and cerebrospinal fluid detection indexes of HIV/AIDS patients with neurosyphilis who received antiretroviral therapy(ART)or not.Methods Patients with HIV/AIDS and neurosyphilis hospitalized in Beijing Ditan Hospital,Capital Medical University,from January 2014 to October 2021 were divided into ART group and non-ART group.The serum and cerebrospinal fluid(CSF)detection indexes of two groups were compared and analyzed.Results A total of 58 patients were enrolled,including 20 cases in the ART group and 38 in the non-ART group.The patients were all male,with a median age of 33.In the non-ART group,the proportion of symptomatic cases(78.9%),the proportion of patients with CD4 cell counts<200cells/μL(68.4%),and patients with opportunistic infections(52.6%)were higher than those in the ART group(25.0%,35.0%,10.0%).The proportion of patients treated with anti-syphilitic therapy in the non-ART group(15.8%)was lower than that in the ART group(90.0%).The CSF-TRUST positive rate(73.7%),the abnormal rate of CSF protein concentrations(84.2%),CSF white blood cell counts(35 cells/μL)and CSF protein concentrations(87.0 mg/dL)in the nonART group were higher than those in the ART group(35.0%,45.0%,14个/μL,41.0 mg/dL).The differences were all statistically significant.Conclusions ART can have a certain impact on the laboratory test indexes of HIV/AIDS patients with neurosyphilis,thereby increasing the difficulty of diagnosis of such patients.
作者
魏春波
赵兴云
袁柳凤
吴焱
刘静
吴冬玲
伦文辉
WEI Chunbo;ZHAO Xingyun;YUAN Liufeng;WU Yan;LIU Jing;WU Dongling;LUN Wenhui(Department of Dermatology,the National Clinical Key Department of Infectious Diseases,Capital Medical University,Beijing 100015,China)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2022年第9期1070-1073,共4页
Chinese Journal of Aids & STD
