摘要
目的探讨苄星青霉素联合头孢三嗪对梅毒患者临床疗效及T淋巴细胞亚群水平的影响。方法选取2015年10月至2019年1月徐州医科大学附属医院诊治的102例梅毒患者作为研究对象,随机数字表法分为研究组(n=51)与对照组(n=51)。对照组患者采取苄星青霉素,研究组在对照组患者基础上加用头孢三嗪,均治疗2周。统计两组患者的临床疗效、RPR转阴率及血清固定率,治疗前后T淋巴细胞亚群指标(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)水平以及不良反应。结果研究组患者总有效率(94.12%)高于对照组患者(80.39%),差异具有统计学意义(P<0.05);研究组患者RPR转阴率(88.24%)高于对照组患者(60.78%),血清固定率(3.92%)低于对照组患者(31.37%),差异具有统计学意义(P<0.05);治疗2周后两组患者CD3^+、CD4^+、CD4^+/CD8^+水平较治疗前增高,CD8^+水平较治疗前降低,且研究组患者CD3^+、CD4^+、CD4^+/CD8^+水平高于对照组患者,CD8^+水平低于对照组患者,差异均具有统计学意义(均P<0.05);研究组患者不良反应发生率(17.65%)与对照组患者(13.73%)比较,差异无统计学意义(P>0.05)。结论采取苄星青霉素联合头孢三嗪治疗梅毒,可提升RPR转阴率、降低血清固定率,调节机体免疫功能,利于提高疾病整体治疗疗效,且具有安全性。
Objective To investigate the effect of benzathine penicillin combined with ceftriaxone on the clinical efficacy and T lymphocyte subsets in patients with syphilis.Methods 102 patients with syphilis in Affiliated Hospital of Xuzhou Medical University from October 2015 to January 2019 were selected and randomly divided into study group(n=51)and control group(n=51).The control group was treated with benzathine penicillin.On the basis of the control group,ceftriaxone was added to the study group.Both groups were treated for 2 weeks.The clinical efficacy,rapid plasma regain(RPR)negative conversion rate and serum fixation rate,T lymphocyte subsets(CD3^+,CD4^+,CD8^+,CD4^+/CD8^+)levels and adverse reactions were evaluated.Results The total effective rate of the study group(94.12%)was higher than that of the control group(80.39%),with statistically significant differences(P<0.05).The mortality rate of the study group(88.24%)was higher than that of the control group(60.78%),and the serum fixation rate(3.92%)was lower than that of the control group(31.37%),with statistically significant differences(P<0.05).After 2 weeks of treatment,the levels of CD3^+,CD4^+,CD4^+/CD8^+in the two groups were higher than those before treatment,and the levels of CD8^+in the study group were lower than those before treatment;the levels of CD3^+,CD4^+,CD4^+/CD8^+in the study group were higher than those in the control group,and the levels of CD8^+in the study group were lower than those in the control group,all with statistically significant differences(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the study group(17.65%)and the control group(13.73%)(P>0.05).Conclusions Benzylpenicillin combined with ceftriaxone in the treatment of syphilis can improve RPR negative conversion rate,reduce serum fixation rate and regulate the immune function,which is conducive to improving the overall therapeutic effect with high safety.
作者
尹涛
YIN Tao(Dermatology Department,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,Jiangsu,China)
出处
《中国性科学》
2020年第8期114-118,共5页
Chinese Journal of Human Sexuality
关键词
梅毒
苄星青霉素
头孢三嗪
T淋巴细胞亚群
RPR转阴率
血清固定率
Syphilis
Benzathine penicillin
Ceftriaxone
T lymphocyte subsets
Rapid plasma regain(RPR)negative conversion rate
Serum fixation rate
