摘要
环状RNA是一类具有特殊共价闭合环状结构的RNA分子,环状RNA锌指核糖核酸结合蛋白(circRNA⁃ZFR)在诸多恶性肿瘤中呈异常表达,并且其表达水平与肿瘤临床分期、癌细胞转移及患者预后密切相关;circRNA⁃ZFR可通过内源竞争性吸附miRNA、调节细胞周期、激活多种信号通路等机制参与调控肿瘤的发生发展。深入研究circRNA⁃ZFR在恶性肿瘤中的表达及作用机制有助于相关肿瘤的早期诊断、靶向治疗和患者预后评估。
Circular RNA is a kind of RNA molecule with special covalent closed circular structure. The existing research results showed that circular RNA zinc finger RNA binding protein(circRNA-ZFR) was abnormally expressed in many malignant tumors, and its expression level was closely related to tumor clinical stage, cell metastasis and patient prognosis. circRNA-ZFR could participate in the regulation of tumor occurrence and development through endogenous competitive adsorption of miRNA, regulation of cell cycle and activation of multiple signal pathways. Further study on the expression and mechanisms of circRNA-ZFR in malignant tumors may support early diagnosis, targeted therapy of related tumors and patients’ prognosis.
作者
刘浪
王海存
高欣
刘广麟
赵俞乔
姜兴明
LIU Lang;WANG Hai-cun;GAO Xin;LIU Guang-lin;ZHAO Yu-qiao;JIANG Xing-ming(Department of Hepatopancreatobiliary Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)
出处
《基础医学与临床》
2022年第10期1585-1590,共6页
Basic and Clinical Medicine
基金
黑龙江省自然科学基金(LH2020H058)
湖北陈孝平科技发展基金(CXPJJH12000002⁃2020015)
国家自然科学基金(81602088)。
