摘要
目的探究鼻腔持续与间歇正压通气结合肺表面活性物质治疗新生儿呼吸窘迫综合征的效果。方法此次共将76例该疾病患儿选入研究中,研究中的起始时间在2018年9月,最终的时间在2019年12月。采用Excel表格将本次研究的患儿相关信息进行统计之后采用随机数字表法分为对照组、观察组,每组38例,分别实施鼻腔持续正压通气结合肺表面活性物质治疗、鼻腔间歇正压通气结合肺表面活性物质治疗,对比治疗效果。结果两组中动脉血氧分压(PaO_(2))、动脉二氧化碳分压(PaCO_(2))、氧合指数(OI)的血气指标对比存在差异性(P<0.05);两组中氧疗时间、无创通气时间以及住院时间的临床指标对比存在差异性(P<0.05)。治疗后,观察组肺气肿、呼吸机相关性肺炎以及鼻/面部损伤发生率较对照组低,观察组总有效率(94.74%)明显高于对照组(71.05%)(P<0.05)。结论对该疾病患儿实施鼻腔间歇正压通气结合肺表面活性物质具有良好的治疗效果,可有效改善患儿的临床症状。
Objective To explore the effect of nasal continuous and intermittent positive pressure ventilation combined with pulmonary surfactant on neonatal respiratory distress syndrome.Methods A total of 76 children with this disease were selected into the study,which started in September 2018 and ended in December 2019.The related information of children in this study was counted by Excel table,and then divided into control group and observation group by random number table method,with 38 cases in each group.The patients were treated with nasal continuous positive pressure ventilation combined with pulmonary surfactant therapy,and intermittent positive pressure ventilation combined with pulmonary surfactant therapy,respectively.Results There were differences in blood gas indexes of arterial oxygen partial pressure(PaO2),arterial carbon dioxide partial pressure(PaCO2)and oxygenation index(OI)between the two groups(P<0.05).There are differences in the clinical indexes of oxygen therapy time,noninvasive ventilation time and hospitalization time between the two groups(P<0.05).After treatment,the incidence of emphysema,ventilator-associated pneumonia,and nose/face injury in the observation group was lower than that in the control group.The total effective rate(94.74%)of the observation group was significantly higher than that of the control group(71.05%)(P<0.05).Conclusion The application of nasal intermittent positive pressure ventilation combined with pulmonary surfactant in children with this disease has a good therapeutic effect and can effectively improve the clinical symptoms of children.
作者
李聪宇
LI Congyu(Department of Pediatrics,Chaoyang Central Hospital,Liaoning Province,Chaoyang 122000,China)
出处
《中国医药指南》
2022年第25期88-90,共3页
Guide of China Medicine
关键词
鼻腔持续通气
间歇正压通气
肺表面活性物质
新生儿呼吸窘迫综合征
Continuous nasal ventilation
Intermittent positive pressure ventilation
Pulmonary surfactant
Neonatal respiratory distress syndrome
