摘要
目的分析低密度脂蛋白(LDL)在H型高血压患者卒中风险分层中的评估作用。方法选取我院收治的H型高血压患者110例,按照卒中风险分层分为两组,低危组67例,中重危组43例,应用单因素及多因素Logistic回归分析探讨增加H型高血压患者合并卒中风险的主要影响因素,同时采用spearman相关性探讨LDL水平及同型半胱氨酸(Hcy)水平的相关性。结果两组患者的性别、年龄、H型高血压病程、合并短暂性脑缺血发作、身体质量指数、吸烟史、酗酒史、合并重度颈动脉狭窄病史、合并心律失常病史、纤维蛋白原水平、部分活化凝血酶原时间、血小板数量、血糖水平无明显差异(P>0.05)。中重危组LDL水平、Hcy水平高于低危组,糖尿病、重度颈动脉狭窄的患病率较高,口服马来酸依那普利叶酸片以及匹伐他汀钙片的患者比例较低(P<0.05)。行多因素Logistic回归分析可见,LDL水平、糖尿病、重度颈动脉狭窄可作为影响H型高血压中重度风险的高危影响因素,而通过口服马来酸依那普利叶酸片及匹伐他汀钙片则是降低H型高血压患者卒中风险的保护因素(P<0.05)。用Spearman相关性分析结果显示LDL及Hcy呈现出了明显的正相关性(P<0.05)。结论LDL水平可作为评估H型高血压卒中风险分层的一类可靠的指标,同时糖尿病及重度颈动脉狭窄可作为影响H型高血压中重度风险的高危影响因素。口服马来酸依那普利叶酸片及匹伐他汀钙片可降低H型高血压患者卒中风险。
Objective To explore assessment role of low-density lipoprotein(LDL)in stroke risk stratification of patients with type H hypertension.Methods 110 patients with type H hypertension in our hospital were selected and divided into low-risk group(n=67)and moderate-severe-risk group(n=43)according to the stroke risk stratification.Logistic regression analysis of single-factor and multi-factors was used to explore the main factors of increasing the stroke risk of patients with type H hypertension,and the spearman correlation was used to explore the correlation between LDL level and Hcy level.Results There was no significant difference in gender,age,duration of type H hypertension,transient ischemic attack,body mass index(BMI),history of smoking,history of alcohol abuse,history of severe carotid artery stenosis,history of arrhythmias,fibrinogen level,partially activated prothrombin time,platelet count,and blood sugar level between the two groups(P>0.05).Compared with the low-risk group,the LDL and Hcy levels in the moderate-severe-risk group were higher,and the morbidity of diabetes and severe carotid artery stenosis was higher,the proportion of patients with oral enalapril maleate folic acid tablets and pitavastatin calcium tablets was lower(P<0.05).Logistic regression analysis of multi-factors showed that LDL level,diabetes and severe carotid artery stenosis can be high-risk factors affecting the moderate to severe risk of type H hypertension,while oral enalapril maleate folic acid tablets and pitavastatin calcium tablets are protective factors that reduce the risk of stroke in patients with type H hypertension(P<0.05).Spearman correlation showed that LDL and Hcy levels hah significant positive correlation(P<0.05).Conclusion LDL level can be used as a reliable indicator for assessing the stroke risk stratification of type H hypertension.At the same time,diabetes and severe carotid artery stenosis can be used as high-risk factors affecting the moderate to severe risk of type H hypertension.Oral enalapril maleate folic
作者
张振华
ZHANG Zhenhua(Juye County People's Hospital,Heze 274900,Shandong)
出处
《菏泽医学专科学校学报》
2022年第3期16-19,39,共5页
Journal of Heze Medical College
关键词
低密度脂蛋白
H型高血压
脑卒中
评估
Low-density lipoprotein
Type H hypertension
Stroke
Evaluation
