摘要
目的探讨红花黄色素对老年H型高血压患者心率变异性(HRV)的影响及部分作用机制。方法将142例老年H型高血压患者用随机数字表法均分为对照组与观察组,每组71例。对照组用马来酸依那普利叶酸片治疗,观察组在对照组治疗的基础上加用红花黄色素注射液。比较2组血压[收缩压(SBP)、舒张压(DBP)]及HRV参数[窦性RR间期总体标准差(SDNN)、5 min RR间期平均值的标准差(SDANN)、相邻RR间期差的均方根(RMSSD)和相邻RR间期差>50 ms占总RR间期数的百分比(PNN50)]变化,治疗前后测定左室结构及舒张功能参数[左室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、二尖瓣舒张早期运动速度与晚期运动速度比值(Ea/Aa)和左心房容积指数(LAVI)],检测外周血同型半胱氨酸(Hcy)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超氧化物歧化酶(SOD)、丙二醛(MDA)、内皮素-1(ET-1)、一氧化氮(NO)、血栓素A(TXA2)、6-酮-前列腺素F1α(6-K-PGF1α)、全血比黏度(WBV)、血浆比黏度(PV)和纤维蛋白原(Fib)。结果治疗后,2组SBP、DBP均降低,且观察组的降幅大于对照组(P<0.05);2组SDNN、SDANN、RMSSD和PNN50均升高,且观察组增幅高于对照组(P<0.05)。治疗后,2组的LVEF和Ea/Aa均高于治疗前,LAVI低于治疗前,且2组比较差异有统计学意义(P<0.05)。治疗后,观察组的LVEDD和LVESD显著降低且低于对照组(P<0.05)。2组Hcy、IL-6、TNF-α、MDA、ET-1、TXA2、WBV、PV和Fib均降低,SOD、NO和6-K-PGF1α均升高,且组间比较差异有统计学意义(P<0.05)。结论红花黄色素治疗老年H型高血压效果良好,可改善患者的HRV并抑制左室舒张功能减低,其机制可能与抗炎、抗氧化应激、保护血管内皮功能及抗血液高凝状态有关。
Objective To investigate the effect and mechanism of safflower yellow on heart rate variability(HRV)in senile patients with H-type hypertension.Methods 142 senile patients with H-type hypertension were randomly divided into control group and observation group,with 71 cases in each group.The control group were treated with Enalapril Maleate Folic Acid Tablets,while the observation group were treated with Safflower Yellow Injections on the basis of control group.The blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)]and HRV parameters[standard deviation of normal RR intervals(SDNN),standard deviation of the averages of NN intervals in all 5-minutes segments of the entire recording(SDANN),root mean square of differences between adjacent NN intervals(RMSSD),percent of NN50 in the total number of NN intervals(PNN50)]were compared between the 2 groups.The left ventricular structure and diastolic function parameters[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),ratio of early diastolic velocity to late diastolic velocity(Ea/Aa),left atrial volume index(LAVI)]were measured before and after treatment.The peripheral blood homocysteine(Hcy),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),superoxide dismutase(SOD),malondialdehyde(MDA),endothelin-1(ET-1),nitric oxide(NO),thromboxane A(TXA2),6 Ketoprostaglandin F1α(6-K-PGF1α),whole blood specific viscosity(WBV),plasma specific viscosity(PV),fibrinogen(Fib)were detected.Results After treatment,the SBP and DBP of the 2 groups decreased,and the decreases of the observation group were greater than that of the control group(P<0.05);the SDNN,SDANN,RMSSD,and PNN50 of the 2 groups increased,and the increases of the observation group were higher than that of the control group(P<0.05).After treatment,the LVEF and Ea/Aa of the 2 groups were higher than before treatment,the LAVI was lower than before treatment,and the differences between the 2 groups were statistically sig
作者
王嘉祺
李志超
张应锐
WANG Jiaqi;LI Zhichao;ZHANG Yingrui(Guangdong Medical University,Dongguan 523000,China;Department of Cardiology,Zhuhai Chinese and Western Integrated Hospital,Zhuhai 519000,China;Department of Cerebral Surgery,Zhuhai Chinese and Western Integrated Hospital,Zhuhai 519000,China)
出处
《西北药学杂志》
CAS
2022年第5期147-152,共6页
Northwest Pharmaceutical Journal
基金
广东省职业技术教育学会课题(编号:201907Z50)。
关键词
红花黄色素
H型高血压
老年患者
心率变异性(HRV)
左室舒张功能
safflower yellow
H-type hypertension
senile patients
heart rate variability(HRV)
left ventricular diastolic function
