摘要
目的探索丙氨酰―谷氨酰胺配合高压氧治疗对中青年缺血性脑卒中患者恢复期外周血T淋巴亚群及微小RNA-124(miR-124)、miR-181c的影响。方法选取2017年7月至2021年7月该院128例中青年缺血性脑卒中恢复期患者作为研究对象,依据随机数字表法分为4组:阴性对照组、对照A组、对照B组、观察组,每组32例。阴性对照组予以脑卒中恢复期常规治疗;在此基础上,对照A组予以丙氨酰―谷氨酰胺治疗;对照B组予以高压氧治疗;观察组予以丙氨酰―谷氨酰胺配合高压氧治疗,均连续治疗4周。比较4组治疗前、治疗2周后、4周后神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、日常生活能力[Barthel指数(BI)]、肢体运动功能[Fugl-Meyer运动功能评分量表(FMA)评分]、炎症因子[肿瘤坏死因子-α(TNF-α)、单核细胞趋化蛋白-1(MCP-1)、白细胞介素12(IL-12)]、外周血T淋巴亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、脑血流动力学[颈动脉最小血流速度(Vmin)、最小血流量(Qmin)]、miR-124、miR-181c表达。结果观察组治疗2周后、4周后NIHSS评分低于对照A组、对照B组和阴性对照组(P<0.05);BI指数高于对照A组、对照B组和阴性对照组(P<0.05);上、下肢肢体运动功能评分高于对照A组、对照B组和阴性对照组(P<0.05)。观察组治疗2周后、4周后血清TNF-α、MCP-1、IL-12水平低于对照A组、对照B组和阴性对照组(P<0.05);CD4^(+)、CD4^(+)/CD8^(+)水平高于对照A组、对照B组和阴性对照组;CD8^(+)低于对照A组、对照B组和阴性对照组(P<0.05)。治疗2周后、4周后对照A组CD4^(+)、CD4^(+)/CD8^(+)高于对照B组和阴性对照组(P<0.05);CD8^(+)低于对照B组和阴性对照组(P<0.05)。观察组治疗2周后、4周后Vmin、Qmin高于对照A组、对照B组和阴性对照组(P<0.05),且对照B组Vmin、Qmin高于对照A组和阴性对照组(P<0.05)。观察组治疗2周后、4周后miR-124、miR-181c表达低于对照A组、对照B�
Objective To explore the effect of alanyl-glutamine combined with hyperbaric oxygen therapy on peripheral blood T lymphocyte subsets,microRNA-124(miR-124),and miR-181c in young and middle-aged patients with ischemic stroke in the convalescent period.Methods A total of 128 young and middle-aged patients with ischemic stroke in the convalescent period in our hospital from July 2017 to July 2021 were selected as the study subjects,and they were divided into 4 groups according to the random number table:negative control group,control group A,control group B,and observation group,with 32 patients in each group.The negative control group received conventional treatment in the convalescent period of stroke.On this basis,the control group A was given alanyl-glutamine;the control group B was given hyperbaric oxygen therapy;the observation group was given alanyl-glutamine combined with hyperbaric oxygen therapy.All treatments lasted for 4 weeks.The neurological function[National Institute of Health Stroke Scale(NIHSS)score],ability of daily living[Barthel index(BI)],limb motor function[Fugl-Meyer Motor Function Assessment score],inflammatory factors[(tumor necrosis factor alpha(TNF-α),monocyte chemoattractant protein-1(MCP-1),and interleukin-12(IL-12)],peripheral blood T lymphocyte subsets(CD4^(+),CD4^(+),and CD4^(+)/CD4^(+)),cerebral hemodynamics[minimum blood flow velocity(V),and minimum blood flow(Q)of the carotid artery],miR-124,and miR-181c expression levels were compared among the 4 groups before treatment and after 2 and 4 weeks of treatment.Results After 2 and 4 weeks of treatment,the NIHSS score in the observation group was significantly lower than that in the control group A,control group B and negative control group(P<0.05),and the BI and motor function scores of upper and lower limbs were significantly higher than those in the control group A,control group B,and negative control group(P<0.05).After 2 and 4 weeks of treatment,serum TNF-α,MCP-1 and IL-12 levels in the observation group were significantly lower
作者
任海蓉
闫兰卓
REN Hai-Rong;YAN Lan-Zhuo(Department of Neurology,The Second People’s Hospital of Jinzhong City,Jinzhong,Shanxi 030800,China)
出处
《国际神经病学神经外科学杂志》
2022年第4期19-25,共7页
Journal of International Neurology and Neurosurgery