摘要
目的观察乌灵胶囊联合失眠认知行为治疗(CBT-Ⅰ)、药物治疗失眠伴焦虑状态的疗效。方法将140例失眠伴焦虑患者随机分为观察组和对照组各70例。对照组采用CBT-Ⅰ与艾司唑仑治疗,其中CBT每周访谈1次,60 min/次,共6周;艾司唑仑1~2 mg/次,1次/d,睡前服用,根据症状调整剂量和时长,服用6周。观察组在对照组基础上加用乌灵胶囊,3粒/次,3次/d,口服,治疗6周。观察两组治疗后临床疗效,治疗前后匹兹堡睡眠质量指数(PSQI)、状态-特质焦虑问卷(STAI)评分,治疗过程中不良反应。结果治疗后观察组总有效率高于对照组(P<0.05)。治疗后,两组PSQI评分、S-AI评分、T-AI评分均降低,观察组评分均低于对照组(P<0.05)。不良反应两组比较,差异无统计学意义(P>0.05)。结论乌灵胶囊联合失眠认知行为治疗(CBT-Ⅰ)与药物治疗失眠伴焦虑状态可提高治疗效果,改善睡眠质量,降低焦虑情绪,不增加不良反应,安全可靠。
Objective To observe the efficacy of Wuling Capsule(乌灵胶囊)combined with cognitive behavioral therapy(CBT-I)and drugs in the treatment of insomnia with anxiety.Methods A total of 140 patients with anxiety insomnia were randomly divided into observation group and control group,70 cases in each group.The control group was treated with GBT-I and estazolam,in which CBT was interviewed once a week,60 min/min for 6 weeks;Estazolam 1~2 mg/time,once a day,before going to bed,adjusting the dose and duration according to the symptoms,and taking it for 6 weeks.On the basis of the control group,the observation group was additionally treated with Wuling Capsuleorally,3 capsules/time,3 times/d,for 6 weeks.The clinical efficacy,PSQI score and STAI score before and after treatment,and adverse reactions during treatment were observed.Results After treatment,the total effective rate of the observation group was higher than that of the control group and the difference was statistically significant(P<0.05).After treatment,the PSQI score,S-AI score and T-AI score of the two groups were decreased,and the scores of the observation group were lower than those of the control group.The differences were statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Wuling Capsule combined with cognitive behavioral therapy for insomnia(CBT-I)and drugs in the treatment of insomnia with anxiety can improve the therapeutic effect and sleep quality,and reduce anxiety without increasing adverse reactions,which is safe and reliable.
作者
胡俊
张静
HU Jun;ZHANG Jing(Gucheng Hospital Affiliated to Hubei University of Arts and Sciences,Gucheng 441700,Hubei,China)
出处
《实用中医内科杂志》
2022年第7期100-102,共3页
Journal of Practical Traditional Chinese Internal Medicine
基金
湖北省自然科学基金(WJ2019F088)。
