摘要
目的:观察调神针法联合艾司唑仑片治疗失眠症伴焦虑的临床疗效及对5-羟色胺(5-HT)、多巴胺(DA)的影响。方法:98例失眠症伴焦虑患者根据随机数字表法分为治疗组、对照组各49例。对照组给予艾司唑仑片治疗,治疗组给予调神针法联合艾司唑仑片治疗,2组连续治疗4周。比较2组治疗前后匹兹堡睡眠质量指数(PSQI)评分、失眠严重程度指数量表(ISI)评分、汉密尔顿焦虑量表(HAMA)评分、睡眠结构参数[睡眠潜伏期、快速眼动睡眠(REM)潜伏期、总睡眠时间、觉醒时间、睡眠效率]及血清神经递质(5-HT、DA)水平,评估2组临床疗效及不良反应发生情况。结果:治疗后,治疗组总有效率95.92%,高于对照组83.67%(P<0.05)。2组治疗后PSQI评分、ISI评分、HAMA评分、睡眠潜伏期、REM潜伏期、觉醒时间及血清DA水平均较治疗前降低(P<0.05),且治疗组PSQI评分、ISI评分、HAMA评分、睡眠潜伏期、REM潜伏期、觉醒时间及血清DA水平低于对照组(P<0.05)。2组治疗后总睡眠时间、睡眠效率及血清5-HT水平较治疗前升高(P<0.05),且治疗组总睡眠时间、睡眠效率及血清5-HT水平高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:调神针法联合艾司唑仑片治疗失眠症伴焦虑疗效确切,能够调节患者神经递质水平,提高睡眠质量及缓解焦虑情绪,安全性较高。
Objective:To observe the clinical effect of mind-regulating acupuncture method combined with Estazolam Tablets on insomnia complicated with depression and its effect on 5-hydroxytryptamine(5-HT)and dopamine(DA).Methods:A total of 98 patients with insomnia and anxiety were divided into the treatment group and the control group according to the random number table method,with 49 cases in each group.The control group was treated with Estazolam Tablets,and the treatment group was treated with mind-regulating acupuncture method and Estazolam Tablets.Both groups were treated continuously for four weeks.The scores of Pittsburgh Sleep Quality Index(PSQI),Insomnia Severity Index(ISI),Hamilton Anxiety Scale(HAMA),as well as levels of sleep structural parameters[sleep latency,rapid eye movement(REM)latency,total sleep time,awakening time,and sleep efficiency],and serum neurotransmitters(5-HT,DA)were compared between the two groups before and after treatment.The clinical efficacy and adverse reactions were evaluated in the two groups. Results: After treatment, thetotal effective rate was 95.92% in the treatment group,higher than that of 83.67% in the control group (P<0.05). After treatment, the scores of PSQI, ISI, and HAMA, sleep latency, REM latency, andawakening time and serum DA levels in the two groups were decreased when compared with those beforetreatment (P<0.05), and the scores of PSQI, ISI, and HAMA, sleep latency, REM latency, andawakening time and serum DA levels in the treatment group were lower than those in the control group (P<0.05). After treatment,the total sleep time and sleep efficiency and serum 5-HT levels in the two groupswere increased when compared with those before treatment (P<0.05),and the total sleep time and sleepefficiency and serum 5-HT levels in the treatment group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Mind-regulating acupuncture method combined with Estazolam
作者
张妤婷
陈凌
ZHANG Yuting;CHEN Ling(Department of Neurology,Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University,Wenzhou Zhejiang 325000,China)
出处
《新中医》
CAS
2024年第15期138-142,共5页
New Chinese Medicine
基金
温州市科技局课题项目(Y20220821)。
关键词
失眠症
焦虑
调神针法
艾司唑仑片
睡眠质量
神经递质
Insomnia
Anxious
Mind-regulating acupuncture method
Estazolam Tablets
Sleep quality
Neurotransmitter
