摘要
目的探讨血清免疫球蛋白E水平与梅尼埃病前庭功能的相关性。方法选取2018年1月—2021年1月内蒙古医科大学附属医院收治的梅尼埃病患者52例作为研究组,同期该院30例体检健康的志愿者作为对照组。比较两组研究对象的临床资料、血清免疫球蛋白E[总免疫球蛋白E(TIgE)、特异性免疫球蛋白E(SIgE)]水平、前庭功能[前庭功能减数值、语音声级、听性脑干反映(ABR)Ⅰ~Ⅴ波间歇期、眼肌前庭诱发肌源性电位(oVEMP)、颈肌前庭诱发肌源性电位(cVEMP)]。比较不同临床分期梅尼埃病患者血清免疫蛋白E水平和前庭功能指标的差异。分析梅尼埃病患者血清免疫蛋白E水平与前庭功能的相关性。绘制受试者工作特征(ROC)曲线,以ROC曲线下面积(AUC)评估血清免疫球蛋白E水平对梅尼埃病患者听力异常严重程度的预测价值。结果研究组血清TIgE、SIgE水平高于对照组(P<0.05);研究组前庭功能减数值、语音声级、ABRⅠ~Ⅴ波间歇期、oVEMP及cVEMP电位值高于对照组(P<0.05)。临床分期Ⅳ期的梅尼埃病患者的血清TIgE和SIgE水平、前庭功能减数值、语音声级、ABRⅠ~Ⅴ波间歇期、oVEMP和cVEMP电位值高于Ⅰ期、Ⅱ期、Ⅲ期患者(P<0.05),Ⅲ期高于Ⅰ期、Ⅱ期(P<0.05),Ⅱ期高于Ⅰ期(P<0.05)。Pearson相关性分析结果显示,梅尼埃病患者TIgE水平与语音声级呈正相关(r=0.583,P=0.007),SIgE水平与前庭功能减数值、语音声级、ABRⅠ~Ⅴ波间歇期、oVEMP电位值、cVEMP电位值呈正相关(r=0.643、0.796、0.589、0.538和0.608,P=0.000、0.000、0.008、0.005和0.002);血清TIgE、SIgE及两者联合预测MD患者听力异常严重程度的敏感性分别为64.29%(95%CI:0.441,0.807)、75.00%(95%CI:0.548,0.886)、64.29%(95%CI:0.441,0.807),特异性分别为75.00%(95%CI:0.530,0.894)、70.83%(95%CI:0.488,0.866)、95.83%(95%CI:0.769,0.998),AUC分别为0.681(95%CI:0.537,0.803)、0.789(95%CI:0.653,0.890)、0.864(95%CI:0.739,0.947)。结论M
Objective To investigate the correlation between serum specific immunoglobulin E(SIgE)level and vestibular function in Ménière's disease(MD).Methods From January 2018 to January 2021,52 patients with Meniere's disease and 30 healthy volunteers who were treated in our hospital during the same period were selected and recorded as the study group and the control group,respectively.Clinical data,serum immune protein E levels[total immunoglobulin E(TIgE),SIgE],auditory vestibular function indexes[vestibular function reduction value,speech frequency,auditory brainstem response(ABR)I to V interval,ocular vestibular evoked myogenic potential(oVEMP),and cervical vestibular evoked myogenic potential(cVEMP)]were compared.The serum immune protein E levels and auditory vestibular function indexes of MD patients with different clinical stages were compared.The relationship between serum immune protein levels and auditory vestibular function in MD patients was analyzed.A receiver operating curve(ROC)was prepared to evaluate the predictive value of serum immune protein levels on the severity of hearing impairment in MD patients by area under the curve(AUC).Results The serum levels of TIgE and SIgE in the study group were higher than those in the control group(P<0.05).The vestibular function reduction value,speech frequency,ABR Ⅰ to Ⅴ interval time,oVEMP and cVEMP potential values in the study group were higher than those in the control group(P<0.05).The levels of serum TIgE,SIgE,vestibular function reduction,speech frequency,ABR Ⅰ to Ⅴ interval time,oVEMP and cVEMP potential values in stage Ⅳ MD patients were all higher than those in stage Ⅰ,Ⅱ,andⅢ(P<0.05).The serum levels of TIgE and SIgE,vestibular function reduction,speech frequency,ABR Ⅰ to Ⅴ interval time,oVEMP and cVEMP potential values in MD patients were all higher than those in stage Ⅰ and stage Ⅱ(P<0.05).The serum TIgE and SIgE levels,vestibular function reduction value,speech frequency,ABR Ⅰ to Ⅴ interval time,oVEMP and cVEMP potential va
作者
崔彦儒
郑艳秋
高伟
Yan-ru Cui;Yan-qiu Zheng;Wei Gao(Department of Otolaryngology and Head and Neck Surgery,Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia Autonomous Region 010059,China)
出处
《中国现代医学杂志》
CAS
北大核心
2022年第17期21-26,共6页
China Journal of Modern Medicine
基金
内蒙古医科大学科技百万工程联合项目[No:YKD2018KJBW(LH)044]。
