摘要
目的通过对梅尼埃病患者进行Ⅰ型变态反应相关检测，探讨Ⅰ型变态反应与梅尼埃病发病的相关性。方法35例确诊梅尼埃病患者，其中男10例、女25例，年龄21-66岁，平均（47．3±13．6）岁；另外选择15例不伴耳鼻疾病的同期咽喉科住院患者作为对照组，其中男5例、女10例，平均年龄（45．4±12．8）岁。检测并比较梅尼埃病组与对照组伴发变态反应的比例、血清总免疫球蛋白E（total immunoglobulin E， tIgE）水平、血清特异性免疫球蛋白E（special immunoglobulin E， sIgE）（包括食物性变应原sIgE和吸入性变应原sIgE）阳性率以及T淋巴细胞亚型分布，并进一步比较伴发与不伴发变态反应梅尼埃病患者眩晕、耳鸣及耳闷胀感的严重程度。结果梅尼埃病患者伴发变态反应的比例为57．1％，对照组为20．0％，差异具有统计学意义（χ^2＝5．832， P〈0．05）；两组间血清tIgE差异具有统计学意义（Z＝168．000，P〈0．05）；梅尼埃病组食物性变应原和吸入性变应原sIgE阳性率与对照组相比，差异均无统计学意义（P值均〉0．05）。伴发变态反应的梅尼埃病患者的眩晕严重度评分、眩晕残障量表评分及耳鸣残障量表评分与不伴变态反应的梅尼埃病患者相比，差异均具有统计学意义（P 值均〈0．05），前者外周血调节性 T 细胞（Treg）水平、Treg／辅助性T 细胞（Th17）比值较后者升高（P值均〈0．05）。结论梅尼埃病患者伴发变态反应的比例较高，Ⅰ型变态反应可能是诱发或加重膜迷路积水导致梅尼埃病的原因之一。
Objective To evaluate the correlation between type Ⅰ allergic reaction and pathogenesis of Meniere′s disease.Methods A total of 35 （10 male vs.25 female） patients aged between 21-66 years diagnosed with Meniere′s disease were recruited to this study , mean age of them was （47.3 ± 13.6） years.The control group consisted of 15 inpatients （5 male vs.10 female） with pharyngolaryngeal diseases but without otologic and rhinologic abnormity , mean age was 45.4 ±12.8 years.Allergic prevalence, serous total immunoglobulin E（ tIgE ） levels, serous specific immunoglobulin E（ sIgE ） levels and subtypes of T lymphocytes were measured and compared in patients with Meniere ′s disease and the control group.Severity of vertigo, tinnitus and sensation of fullness were compared between Meniere′s disease patients with or without allergy .Results Allergic prevalence were significantly different （ Pearson chi-square 5.832, P 〈0.05 ） between patients with Meniere′s disease and the control group （ 57.1% vs. 20.0%） .Patients with Meniere′s disease report higher level of serous tIgE compared with controls , the difference is statistically significant （Z =168.000,P 〈0.05）.However, positive rates of sIgE of food allergens and inhalant allergens were not significantly different between patients with Meniere ′s disease and the control group .Scores of vertiginous severity , dizziness handicap inventory （ DHI） and tinnitus handicap inventory （ THI） were significantly different between Meniere′s disease patients with or without allergy （ P〈0.05）.Treg and Treg/Th17 levels （Z=26.000） were much higher in Meniere′s disease patients with allergy than in the controls（P〈0.05）.Conclusions Patients with Meniere′s disease report higher rate of allergy than the control group .TypeⅠallergic reaction is thought to be one of the possible reasons that may induce endolymphatic hydrops and lead to Meniere′s disease.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2017年第2期89-92,共4页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金
国家自然科学基金（21272018）
首都卫生发展科研专项项目（2016-2-4094）
