摘要
目的 探讨早期胃癌术后感染患者血清肿瘤坏死因子-α(TNF-α)、二胺氧化酶(DAO)、肠脂肪酸结合蛋白(IFABP)水平及与胃肠功能恢复的相关性。方法 选取2016年1月-2020年12月连云港市第一人民医院收治的100例早期胃癌手术患者,根据术后3 d是否发生手术部位感染分为感染组17例、未感染组83例,比较两组一般资料、术前和术后3 d血清胃泌素、胃动素、TNF-α、DAO、IFABP水平,采用Pearson分析血清TNF-α、DAO、IFABP水平与胃肠功能恢复的相关性,采用受试者工作特征曲线(ROC)及曲线下面积(AUC)分析血清TNF-α、DAO、IFABP预测感染的价值。结果 感染组术前、术后3 d TNF-α、DAO、IFABP高于未感染组(P<0.05);感染组术前、术后3 d胃泌素、胃动素低于未感染组(P<0.05);术前血清TNF-α、DAO、IFABP与术前胃泌素、胃动素呈负相关(P<0.05);血清TNF-α、DAO、IFABP预测感染的AUC依次为0.791、0.833、0.755;血清TNF-α+DAO+IFABP预测感染的AUC为0.936(P<0.05)。结论 早期胃癌术后感染患者血清TNF-α、DAO、IFABP升高与胃肠功能恢复有关,有望成为预测术后感染的分子标志物,对感染高风险者采取一定干预,预防感染的发生,对促进术后胃肠功能恢复具有积极意义。
OBJECTIVE To investigate the serum tumor necrosis factor-α(TNF-α), diamine oxidase(DAO) and intestinal fatty acid binding protein(IFABP) levels in patients with postoperative infection of early gastric cancer and their correlation with the recovery of gastrointestinal function. METHODS A total of 100 patients undergoing surgery for early gastric cancer admitted to the First People′s Hospital of Lianyungang City from Jan 2016 to Dec 2020 were selected and divided into 17 cases of infected group and 83 cases of uninfected group according to whether infection occurred 3 days after surgery. The general data, serum gastrin, motilin, TNF-α, DAO and IFABP levels were compared between the two groups before and 3 days after operation. Pearson was used to analyze the correlation between serum TNF-α, DAO, IFABP levels and the recovery of gastrointestinal function. Receiver operating characteristic(ROC) and area under the curve(AUC) were used to analyze the value of serum TNF-α, DAO, and IFABP for the prediction of infection. RESULTS The TNF-α, DAO, and IFABP of the infection group were significantly higher than those of the uninfected group before and 3 days after the operation(P<0.05);the gastrin and motilin of the infected group were significantly lower than those of the uninfected group before and 3 days after the operation(P <0.05);Preoperative serum TNF-α, DAO, IFABP were negatively correlated with preoperative gastrin and motilin(P<0.05);The AUC of Serum TNF-α, DAO, IFABP for the prediction of infection was 0.791, 0.833, and 0.755, respectively;The AUC of combined serum TNF-α, DAO, and IFABP for the prediction of infection was 0.936(P<0.05). CONCLUSION The increase of serum TNF-α, DAO and IFABP in patients with postoperative infection of early gastric cancer was related to the recovery of gastrointestinal function, which was expected to be a molecular marker for predicting postoperative infection. Taking certain interventions for those at high risk of infection to prevent the occurrence of infection was of
作者
徐大洲
孙运良
靳卫权
张树贤
王璐
梁旭阳
张志梅
XU Da-zhou;SUN Yun-liang;JIN Wei quan;ZHANG Shu-xian;WANG Lu;LIANG Xu-yang;ZHANG Zhi-mei(Lianyungang First People's Hospital,Lianyungang,Jiangsu 222000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2022年第3期434-438,共5页
Chinese Journal of Nosocomiology
基金
江苏省卫生科技基金资助项目(ZD1903)。
关键词
早期胃癌
肿瘤坏死因子-α
二胺氧化酶
肠脂肪酸结合蛋白
胃肠功能恢复
相关性
Early gastric cancer
Tumor necrosis factor-α
Diamine oxidase
Intestinal fatty acid binding protein
Gastrointestinal function
Correlation
