摘要
目的探讨益生菌在新辅助化疗+胃癌根治术老年患者中的应用效果。方法依据治疗方式的不同将90例老年胃癌患者分为对照组和观察组,每组45例,对照组患者给予新辅助化疗+胃癌根治术治疗,观察组患者给予益生菌联合新辅助化疗+胃癌根治术治疗。比较两组患者的预后相关指标、免疫功能指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、营养状况指标和并发症发生情况。结果观察组患者的首次肛门排气时间、首次排便时间、固体食物耐受时间、术后住院时间均明显短于对照组,差异均有统计学意义(P﹤0.01)。治疗后,两组患者CD4^(+)、CD8^(+)水平和CD4^(+)/CD8^(+)均低于本组治疗前,观察组患者CD4^(+)水平和CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者总蛋白、白蛋白、前白蛋白水平均高于本组治疗前,观察组患者总蛋白、白蛋白、前白蛋白水平均高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者并发症总发生率为11.11%,低于对照组患者的40.00%,差异有统计学意义(P﹤0.05)。结论新辅助化疗和胃癌根治术后联合使用益生菌,有助于改善老年胃癌患者的胃肠功能、免疫功能和营养状态,降低术后感染及胃肠道相关并发症发生率。
Objective To investigate the application effect of probiotics in elderly patients undergoing neoadjuvant chemotherapy and radical gastrectomy for gastric cancer.Method A total of 90 elderly patients with gastric cancer were divided into control group and observation group according to different treatment methods,with 45 cases in each group.Patients in the control group were treated with neoadjuvant chemotherapy+radical gastrectomy,and patients in the observation group were treated with probiotics combined with neoadjuvant chemotherapy+radical gastrectomy.The prognosisrelated indicators,immune function indicators(CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),nutritional status indicators,and occurrence of complications were compared between the two groups.Result The first anal exhaust time,first defecation time,solid food tolerance time,and postoperative hospitalization time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.01).After the treatment,the levels of CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)in the two groups were lower than those before the treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher,while the CD8^(+)level was lower than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the total protein,albumin,and prealbumin levels of the two groups were higher than those before the treatment,the three index levels of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).The total incidence rate of complications in the observation group was 11.11%,which was lower than 40.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion It is of benefit to use probiotics after neoadjuvant chemotherapy and radical gastrectomy as their combination do help to improve gastrointestinal function,immune function,and nutritional status of elderly patients with gastri
作者
刘玉曼
李淑莹
燎原
LIU Yuman;LI Shuying;LIAO Yuan(Second Department of Geriatric Comprehensive,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Department of Medical,He’nan Provincial People’s Hospital,Zhengzhou 450000,He’nan,China)
出处
《癌症进展》
2023年第19期2147-2149,2173,共4页
Oncology Progress
关键词
新辅助化疗
胃癌
胃癌根治术
益生菌
免疫功能
neoadjuvant chemotherapy
gastric cancer
radical gastrectomy
probiotics
immune function
