摘要
目的探究疏肝解郁汤对血管神经性头痛患者脑动脉血流速度的影响。方法选取114例于2018年1月—2020年5月到朔城区第二人民医院进行就诊的血管神经性头痛患者,应用随机数字表法将全体患者分为2组,对照组57例,观察组57例。2组行相同基础治疗及入院检查,对照组患者予左乙拉西坦口服,观察组在此基础上加予疏肝解郁汤治疗,2组患者连续行12周治疗。对比2组患者疗效、治疗前后中医症状积分变化情况及生活质量变化情况、治疗前后血流动力学、脑动脉血流指标变化情况以及治疗前后CGRP、SP表达水平。结果观察组的总有效率高于对照组(P<0.05);经过12周的治疗,2组患者积分均降低(P<0.05),且相对于对照组,观察组更低(P<0.05);治疗后,2组患者生活质量评分均有所降低(P<0.05),观察组生活质量更好;2组患者的搏动指数和脑动脉血流速度均有所降低(P<0.05),且相对于对照组,观察组患者的脑动脉血流速度和搏动指数更低(P<0.05);2组患者红细胞比容,血浆黏度及纤维蛋白原表达均有所降低(P<0.05),且观察组患者的红细胞比容,血浆黏度及纤维蛋白原表达低于对照组(P<0.05)。治疗后,血清CGRP、SP水平均下降(P<0.05),且观察组患者血清CGRP、SP水平较对照组更低(P<0.05)。结论疏肝解郁汤治疗血管神经性头痛能改善患者脑动脉血流速度及血流动力学指标,且可降低血清CGRP、SP表达,改善生活质量,治疗有效率高。
Objective To explore the effect of Shugan Jieyu decoction on the blood flow velocity of cerebral artery in patients with angioneurotic headache.Methods A total of 114 patients with vascular neuropathic headache who came to Shuocheng Second People’s Hospital between January 2018 and May 20120 were selected.All patients were divided into two groups by random number method,with 57cases in the control group and 57 cases in the observation group.The two groups received the same basic treatment and admission examination,the control group was given levetiracetam injection after completing admission examination,and the observation group was additionally given Shugan Jieyu decoction on this basis,and the two groups received continuous treatment for 12 weeks.The therapeutic efficacy of 2 groups were compared,the changes of traditional Chinese medicine symptom scores and quality of life in 2 groups before and after treatment were compared,the changes of hemodynamics and cerebral artery blood flow indexes in 2 groups before and after treatment were compared,and the expression levels of CGRP and SP in 2 groups before and after treatment were compared.Results After treatment,the effective rate of the observation group treated with Shugan Jieyu decoction was higher than that of the control group(P<0.05).The scores of the two groups of patients were lower than before treatment(P<0.05),the observation group was better than the control group(P<0.05);The scores of the two groups of patients decreased(P<0.05),and the scores of the observation group were lower than the control group(P<0.05).The pulsatility index and cerebral arterial blood flow velocity of the two groups of patients decreased(P<0.05),and the pulsation index and cerebral arterial blood flow velocity of the observation group were lower than those of the control group(P<0.05).After treatment,the hematocrit,plasma viscosity and fibrinogen expression of the two groups of patients were reduced(P<0.05),and the observation group had low hematocrit,plasma viscosity and fibr
作者
李金全
梁翠萍
李俊娥
LI Jinquan;LIANG Cuiping;LI Jun'e(Department of Traditional Chinese Medicine,Shuocheng Second People's Hospital,Shanxi Province,Shuozhou 036000,China)
出处
《光明中医》
2022年第13期2285-2288,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
关键词
疏肝解郁汤
血管神经性头痛
中医药疗法
Shugan Jieyu decoction
angioneurogenic headache
therapy of TCM
