摘要
目的评价抗结核药物联合莫西沙星治疗脊柱结核临床疗效及意义。方法收集2018年6月至2020年6月我院难治性脊柱结核(复发性脊柱结核、老年性脊柱结核及合并肝功能异常无法正规抗结核治疗脊柱结核)病例60例。随诊观察(1)午后潮热、盗汗、局部疼痛等症状消失的时间,窦道愈合时间;(2)血沉及C反应蛋白转为正常的时间;(3)X线片显示骨性融合的时间,磁共振提示椎旁脓肿消失时间。结果治疗组:午后潮热、盗汗、局部疼痛等症状消失及窦道愈合时间,血沉及C反应蛋白转为正常的时间均较对照组时间缩短,X线片显示骨性融合的时间、磁共振提示椎旁脓肿消失时间均早于对照组。差异均有统计学意义(P<0.05),比较对照组,治疗组患者的功能障碍评分明显降低(P<0.05)。结论莫西沙星联合利福平、异烟肼、乙胺丁醇、吡嗪酰胺药物治疗脊柱结核的一种很好的协助治疗,特别是难治性脊柱结核,能缩短疗程,提高治愈率。
Objective To evaluate the clinical efficacy and significance of anti-tuberculosis drugs combined with Moxisha county in the treatment of spinal tuberculosis.Methods From June 2018 to June 2020,60 cases of refractory spinal tuberculosis(recurrent spinal tuberculosis,senile spinal tuberculosis,drug-resistant spinal tuberculosis and complicated with abnormal liver function which cannot be treated with normal anti-tuberculosis)in our hospital were collected.Follow-up observation(1)The time when afternoon hot flashes,night sweats,local pain and other symptoms disappeared,and the time of sinus healing;(2)Time for esR and C-reactive protein to return to normal;(3)Radiographs showed the time of bone fusion,and Mr Suggested the time of paravertebral abscess disappearance.Results In the treatment group,the symptoms such as afternoon hot flashes,night sweats and local pain disappeared and the time of sinus healing,the time of erythrocyte sedimentation rate and C-reactive protein returning to normal was shorter than that in the control group.The time of bone fusion on X-ray film and the time of paravertebral abscess disappeared suggested by MAGNETIC resonance were earlier than that in the control group.The differences were statistically significant(P<0.05).Compared with the control group,the dysfunction score of the treatment group was significantly lower(P<0.05).Conclusion Moxifloxacin combined with rifampicin,isoniazid,ethambutol and pyrazinamide is a good adjuvant treatment for spinal tuberculosis,especially for refractory spinal tuberculosis,which can shorten the course of treatment and improve the cure rate.
作者
桂燃燃
李明
刘琳娜
柯文坤
孔德胜
GUI Rangran;LI Ming;LIU Linna(Department of Orthopaedics,Jiujiang Third People’s Hospital,Jiangxi Province,Jiujiang 332000)
出处
《江西医药》
CAS
2022年第7期692-694,710,共4页
Jiangxi Medical Journal
基金
九江市指导性科技计划项目,编号S2021ZDYFN185。
关键词
莫西沙星
难治性脊柱
临床疗效研究
Moxifloxacin
Refractory spine
Clinical efficacy study
