摘要
目的社区获得性肺炎是临床常见疾病,近年患病率呈逐渐上升趋势,若不接受规范治疗,可引起心功能及呼吸衰竭,危及患者生命安全。本研究探讨莫西沙星对社区获得性肺炎患者血清C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)、白介素-6(interleukin-6,IL-6)及T淋巴细胞亚群的影响。方法选取新乡市妇幼保健院2017-01-10-2019-03-15收治的社区获得性肺炎患者84例,采用组间性别、年龄均衡的原则分为观察组(42例)和对照组(42例)。对照组采用左氧氟沙星序贯治疗,观察组采用莫西沙星序贯治疗,治疗2个周期后,对比两组患者临床疗效、炎性因子(CRP、PCT、IL-6)、T淋巴细胞亚群水平和不良反应发生率。结果治疗后,观察组临床总有效率为92.86%,高于对照组的76.19%,差异有统计学意义,χ2=4.459,P=0.035。观察组CRP为(3.23±1.45)mg/L,低于对照组的(5.38±1.74)mg/L,t=6.152,P<0.001;PCT为(0.18±0.06)μg/L,低于对照组的(0.29±0.07)μg/L,t=10.544,P<0.001;IL-6为(1.58±0.87)ng/L,低于对照组的(2.63±1.02)ng/L,t=5.076,P<0.001。治疗后观察组CD4+为(41.23±7.04)%,高于对照组的(35.92±6.28)%,t=3.648,P=0.001;CD4+/CD8+为2.58±0.34,高于对照组的1.97±0.48,t=6.721,P<0.001;CD8+为(18.24±4.86)%,低于对照组的(23.57±5.49)%,t=4.711,P<0.001。对照组不良反应发生率为16.67%,与观察组14.29%比较,差异无统计学意义,χ2=0.091,P=0.763。结论社区获得性肺炎采用莫西沙星序贯治疗可提高临床疗效,降低血清炎性因子水平,改善T淋巴细胞亚群水平,且不良反应少,安全性较高。
OBJECTIVE Community-acquired pneumonia is a common clinical disease.In recent years,the prevalence of the disease has gradually increased.If it does not receive standardized treatment,it can cause heart function and respiratory failure,thus endangering patient’s life.This study aims to investigate the effect of moxifloxacin on serum C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)and T-lymphocyte subsets in patients with community-acquired pneumonia.METHODS A total of 84 patients with community-acquired pneumonia who admitted in Maternal and Child Health Care Hospital of Xinxiang from January 10,2017 to March 15,2019 were selected as subjects,and they were divided into observation group(42 cases)and control group according to the principle of balanced gender and age between groups.Control group was given levofloxacin sequential therapy,and observation group was given moxifloxacin sequential therapy.After the treatment for two courses,the clinical efficacy,inflammatory factors(CRP,PCT,IL-6),T-lymphocyte subsets,and the incidence of adverse reactions were compared between two groups.RESULTS After treatment,the clinical total efficiency of observation group(92.86%)was higher than that of control group(76.19%),χ2=4.459,P=0.035.After treatment,the levels of CRP,PCT and IL-6 in observation group[(3.23±1.45)mg/L,(0.18±0.06)μg/L,(1.58±0.87)ng/L]were lower than those in control group[(5.38±1.74)mg/L,(0.29±0.07)μg/L,(2.63±1.02)ng/L],t values were 6.152,10.544 and 5.076,all P<0.001.After treatment,the levels of CD4+and CD4+/CD8+in observation group[(41.23±7.04)%,(2.58±0.34)]were higher than those in control group[(35.92±6.28)%,(1.97±0.48)],and the level of CD8+in observation group[(18.24±4.86)%]was lower than that in control group[(23.57±5.49)%],t values were 3.648,6.721 and 4.711,Pvalues were 0.001,<0.001 and<0.001.There was no statistical difference in the incidence of adverse reactions between control group(16.67%)and observation group(14.29%),χ2=0.091,P=0.763.CONCLUSION Moxifloxacin in tr
作者
陈英
李爱琴
杨洪娟
CHEN Ying;LI Ai-qin;YANG Hong-juan(Department of Pharmacy,Maternal and Child Health Care Hospital of Xinxiang,Xinxiang 453003,P.R.China)
出处
《社区医学杂志》
2020年第8期599-602,共4页
Journal Of Community Medicine
