摘要
目的总结左侧颞叶癫痫患者工作记忆维持期神经振荡模式特征,探讨左侧颞叶癫痫伴工作记忆障碍的神经机制。方法共纳入21例2017年9月至2021年5月在天津医科大学总医院诊断与治疗的左侧颞叶癫痫患者(LTLE组),另以性别、年龄、受教育程度和认知功能相匹配的35例健康志愿者为对照(对照组),完成视觉工作记忆测试,记录反应时间和应答正确率;同时采集34通道脑电信号,计算工作记忆维持期各频段功率谱密度(PSD),选取PSD最高频段作为工作记忆维持期优势频段并分析优势频段神经振荡空间分布模式。结果工作记忆行为学分析,与对照组相比,LTLE组完成工作记忆反应时间延长(t=3.597,P=0.001),应答正确率降低(t=3.770,P=0.001)。神经振荡模式分析,θ频段为工作记忆维持期优势频段,且θ频段PSD主要集中于额区,尤以额中线Fz通道分布密集;与对照组相比,LTLE组工作记忆维持期全脑(t=2.600,P=0.012)、额区(t=2.252,P=0.029)、Fz通道(t=2.496,P=0.016)θ频段工作记忆效应PSD(PWM)均降低。结论左侧颞叶癫痫患者存在工作记忆障碍,且视觉工作记忆维持期θ振荡减弱。θ振荡减弱有可能成为评估颞叶癫痫患者工作记忆障碍的敏感指标。
ObjectiveTo summarize the characteristics of neural oscillation during the workingmemory maintenance in patients with left temporal lobe epilepsy(LTLE),and to explore the changes ofneural oscillations in working memory disorders.MethodsA total of 21 patients with LTLE(LTLE group)admitted to Tianjin Medical University General Hospital from September 2017 to May 2021 and 35 healthycontrols(control group)with matched gender,age,education and cognitive function were enrolled.Thevisual working memory test was performed,response time and accuracy were recorded.Thirty-four channelsof EEG signals were collected to calculate the power spectral density(PSD)of each frequency band duringworking memory maintenance.The PSD and spatial distribution of dominant frequency bands duringworking memory maintenance were compared between 2 groups.ResultsCompared with the controlgroup,LTLE group had longer response time(t=3.597,P=0.001)and lower accuracy(t=3.770,P=0.001).θfrequency band was the dominant band during working memory maintenance,and the PSD ofθfrequencyband was mainly concentrated in the frontal region,especially the Fz channel of frontal midline.Comparedwith the control group,the P_(WM) of θ frequency band of the whole brain(t=2.600,P=0.012),frontal region(t=2.252,P=0.029)and Fz channel(t=2.496,P=0.029)in LTLE group decreased.ConclusionsLTLEpatients with working memory disorders,and decreasedθoscillation during working memory may be asensitive indicator of working memory disorders in patients with temporal lobe epilepsy.
作者
潘立平
宋毅军
PAN Li-ping;SONG Yi-jun(Department of General Medicine,Tianjin Medical University General Hospital,Tianjin Neurological Institute,Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System,Ministry of Education,Tianjin 300052,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2022年第7期564-569,共6页
Chinese Journal of Contemporary Neurology and Neurosurgery
基金
天津市医学重点学科建设项目
天津市卫生健康委科技项目(项目编号:TJWJ2021MS001)
天津市重点研发计划科技支撑重点项目(项目编号:20YFZCSY00010)
天津医科大学总医院青年专业技术骨干培养计划项目。
关键词
癫痫
颞叶
记忆
短时
Θ节律
脑电描记术
Epilepsy,temporal lobe
Memory,short-term
Theta rhythm
Electroencephalography
