摘要
目的研究分析高压氧辅助丁苯酞治疗急性脑缺血脑卒中患者的应用。方法本次研究对象为我院接受治疗的急性脑缺血性脑卒中患者,开展时间在2020年1月至2022年1月,此时间内共收治了86例患者,将其进行分组,分为观察组和对照组,每组43例,分组方法为随机数字表法。两组患者均采取丁苯酞治疗,观察组则在此基础上予以高压氧辅助治疗。对比分析两组的临床疗效。结果治疗后,观察组与对照组的NIHSS评分和MMSE评分较治疗前明显更优,且观察组NIHSS评分低于对照组,MMSE评分高于对照组,差异均有统计学意义(P<0.05);临床治疗总有效率两组比较,观察组显著高于对照组,差异有统计学意义(P<0.05);治疗后,观察组与对照组的ET-1、TXB2和VEGF水平较治疗前更优,且观察组ET-1、TXB2水平低于对照组,VEGF水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组与对照组的TT、PT、APTT指标水平较治疗前升高,且观察组均明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组与对照组的纤维蛋白原、红细胞压积以及全血黏度指标水平较治疗前下降,且观察组各项指标数据均低于对照组,差异有统计学意义(P<0.05);不良反应发生率两组进行对比分析,数据间并无显著差异,差异无统计学意义(P>0.05)。结论在畸形缺血性脑卒中患者的临床治疗中,予以高压氧辅助丁苯酞治疗较单纯丁苯酞治疗临床疗效更明显,患者的神经和认知功能均得到了明显改善,并且对血管内皮损伤减轻,能够有效改善患者的凝血功能和血液流变学,治疗期间不良反应未有明显增加,具有较高的安全性。
Objective To study and analyze the application of hyperbaric oxygen assisted butylphthalide in the treatment of patients with acute cerebral ischemic stroke.Methods The subjects of this study were patients with acute cerebral ischemic stroke who were treated in our hospital.The period was from January 2020 to January 2022.During this period,a total of 86 patients were admitted and divided into groups.Divided into observation group and control group,43 cases in each group,the grouping method was random number table method.Both groups were treated with butylphthalide,and the observation group was given hyperbaric oxygen adjuvant therapy on this basis.The clinical efficacy of the two groups was compared and analyzed.Results After treatment,the NIHSS scores and MMSE scores of the observation group and the control group were significantly better than those before treatment,and the NIHSS score of the observation group was lower than that of the control group,and the MMSE score of the observation group was higher than that of the control group,with statistical significance(P<0.05).Compared the total effective rate of clinical treatment between the two groups,the observation group was significantly higher than the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of ET-1,TXB2 and VEGF in the observation group and the control group were higher than those before treatment and the levels of ET-1 and TXB2 in the observation group were lower than those in the control group,and the levels of VEGF were higher than those in the control group,and the difference was statistically significant(P<0.05).The levels were higher than those before treatment,and the observation group was significantly higher than the control group,and the difference was statistically significant(P<0.05).Compared with before treatment,the index data of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions was
作者
方斌
张碧蘅
FANG Bin;ZHANG Biheng(The First People's Hospital of Jiujiang City,Jiujiang,332000,China;Affiliated Hospital of Jiujiang University,Jiujiang 332000,China)
出处
《中国医药指南》
2022年第22期29-32,共4页
Guide of China Medicine
关键词
高压氧
丁苯酞
缺血性脑卒中
临床疗效
Hyperbaric oxygen
Butylphthalide
Ischemic stroke
Clinical efficacy