摘要
口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是口腔颌面部最常见的恶性肿瘤,而OSCC患者就诊时往往疾病已发展到晚期阶段并出现肿瘤转移,导致预后不佳。OSCC的发病机制尚不清楚,目前早期有效监测OSCC发生、侵袭、转移及复发的分子靶点仍需要进一步探究。当前的研究显示,各种组蛋白修饰改变了染色质结构,进而影响相关下游基因的转录活性,调控基因表达水平,在OSCC的生物学检测、病理分级与分期、预后判断中均发挥重要作用。该文主要对组蛋白的甲基化、乙酰化、磷酸化、泛素化、二磷酸腺苷核糖基化等修饰在OSCC中的研究进展进行综述。
Oral squamous cell carcinoma(OSCC)is the most common malignant tumor in the oral and maxillofacial region,but when OSCC patients seek medical advice,the disease has often reached an advanced stage and tumor metastasis has appeared,resulting in a poor prognosis.Its pathogenesis is still unclear,and there is still demand for effective diagnostic and therapeutic targets to monitor the invasion,metastasis and recurrence of OSCC.Studies show that histone modification changes chromatin structure,thereby affecting transcriptional activity of related downstream genes and regulating gene expression levels,which plays an important role in biological detection,pathological grading and staging,prognosis of OSCC.This article reviews current research progress of histone modification including methylation,acetylation,phosphorylation,ubiquitination and ADP-ribosylation in oral squamous cell carcinoma.
作者
侯伊明
李娜
禹文茜
陈磊
HOU Yiming;LI Na;YU Wenqian;CHEN Lei(Department of Orthodontics,School and Hospital of Stomatology,Cheeloo College of Medicine,Shandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,Jinan 250012,China)
出处
《口腔医学》
CAS
2022年第7期650-654,共5页
Stomatology
基金
国家自然科学基金(61771290,82002987)
泰山学者项目(tsqn201812137)
山东大学基本科研业务经费(人才引进与培养类专项)2019GN091。
关键词
口腔鳞状细胞癌
组蛋白修饰
标志物
靶向治疗
oral squamous cell carcinoma
histone modification
biomarker
molecular targeted therapy
