摘要
目的探讨非男方因素早发性卵巢功能不全(Primary ovarian insufficiency,POI)患者采用不同受精方式对助孕结局的影响。方法回顾性分析2018年1月-2021年5月新疆医科大学第一附属医院生殖医学中心收治的161例POI患者为研究对象,按照不同受精方式分为两组:体外受精(In vitro fertilization,IVF)组(n=112),卵胞浆内单精子显微注射(Intracytoplasmic sperm injection,ICSI)组(n=49)。记录两种不同方式受精后的受精率、2PN受精率、卵裂率、2PN卵裂率、可利用胚胎率、优质胚胎率、囊胚形成率,形成胚胎后行新鲜胚胎移植或行冻融胚胎解冻移植,随访至活产为周期结束,比较两种不同受精方式的累积生化妊娠率、累积临床妊娠率、累积胚胎种植率、累积流产率、累积异位妊娠率、累积活产率、胎儿的男女性别比。结果两组患者一般资料的比较及累积生化妊娠率、累积临床妊娠率、累积种植率、累积流产率、累积异位妊娠率、累积活产率差异无统计学意义(P>0.05),与IVF组比较,ICSI组的2PN受精率(72.68%)、卵裂率(98.16%)、2PN卵裂率(90.80%)增高,可利用胚胎率(64.86%)、优质胚胎率(16.22%)、胎儿男女性别比(0.36∶1)降低,差异有统计学意义(P<0.05)。结论非男方因素行辅助生殖技术治疗的POI患者,ICSI不能改善其妊娠结局。
Objective To investigate the outcome of assisted pregnancy in patients with non-male-factors-POI in different fertilization methods.Methods Using retrospective-analysis in 161 POI patients who sought medical advice in the hospital from January 2018 to May 2021.The 161 patients were divided into two groups in different fertilization methods:IVF group(n=112),ICSI group(n=49).The fertilization rate,2PN fertilization rate,cleavage rate,2PN cleavage rate,available embryo rate,high-quality embryo rate,blastocyst formation rate after two different fertilization methods were recorded.After the formation of embryos,fresh embryo transfer or freeze-thaw embryo thawing transplantation was performed.Follow-up was performed until the end of the live birth cycle.The cumulative biochemical pregnancy rate,cumulative clinical pregnancy rate,cumulative embryo implantation rate,cumulative abortion rate,cumulative ectopic pregnancy rate,cumulative live birth rate and fetal sex ratio were compared between the two fertilization methods.Results There were no statistical differences in basic data,included the cumulative-biochemical pregnancy rate,cumulative-clinical pregnancy rate,cumulative-embryo implantation rate,cumulative abortion rate,available embryo rate,highquality embryo rate,blastocyst formation rate,cumulative-ectopic-pregnancy rate,and cumulative-live-birth rate(P>0.05)between the two groups.Compared with IVF group,2PN fertilization rate(72.68%),cleavage rate(98.16%),2PN cleavage rate(90.80%)were higher in ICSI group,available embryo rate(64.86%),high-quality embryo rate(16.22%),sex-ratio(0.36∶1)were lower in ICSI group,and there was statistically significant(P<0.05).Conclusion ICSI can not improve pregnancy outcomes in POI patients treated with non-male assisted reproductive technology.
作者
刘晨
王静怡
张于念
腊晓琳
LIU Chen;WANG Jingyi;ZHANG Yunian;LA Xiaolin(Department of Assisted Reproductive Technology,the First Affiliated Hospital,State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Xinjiang Medical University,Urumqi 830054,China)
出处
《新疆医科大学学报》
CAS
2022年第7期733-737,共5页
Journal of Xinjiang Medical University
基金
省部共建中亚高发病成因与防治国家重点实验室开放课题资助项目(SKL-HIDCA-2020-JZ4)。
