摘要
目的探讨不同受精方式治疗非男性因素不孕高龄女性患者的效果。方法选取2017年1月至2019年12月同济大学附属第一妇婴保健院生殖医学中心606例非男性因素不孕高龄女性患者,根据受精方式分为常规体外受精(IVF)组(421例)和卵胞浆内单精子注射(ICSI)组(185例)。比较两组的临床结局及子代出生情况。结果两组受精率、囊胚形成率比较,差异有统计学意义(P<0.05);两组卵裂率、D3可用胚胎率、D3优质胚胎率、临床妊娠率、种植率比较,差异无统计学意义(P>0.05)。两组孕龄、出生体重、出生率、低体重儿出生率、早产率比较,差异无统计学意义(P>0.05)。结论在非男性因素不孕高龄女性患者中,常规IVF治疗比ICSI可以获得更高的受精率和囊胚形成率,且ICSI治疗非男性因素不孕症并不能提高其种植率和出生率。
Objective To evaluate the effect of different fertilization methods in advanced maternal age patients with non-male factor infertility.Methods A total of 606 cases of advanced maternal age patients with non-male factor infertility in Reproductive Medicine Center,Shanghai First Maternity and Infant Hospital,Tongji University,from January 2017 to December 2019 were enrolled.They were devided into in vitro fertilization(IVF)group(421 cases)and intracytoplasmic sperm injection(ICSI)group(185 cases)according to the fertilization method.Clinical outcomes and offspring birth were compared between two groups.Results There were significant differences in fertilization rate and blastocyst formation rate between two groups(P<0.05).There were no significant differences in cleavage rate,D3 available embryo rate,D3 high-quality embryo rate,clinical pregnancy rate,and implantation rate between two groups(P>0.05).There were no significant differences in gestational age,birth weight,birth rate,low body weight birth rate,and premature birth rate between two groups(P>0.05).Conclusion In advanced maternal age patients with non-male infertility,conventional IVF treatment resulted in higher rates of fertilization and blastocyst formation than ICSI,and ICSI treatment of non-male infertility do not improve the implantation rate and birth rate.
作者
柳亚南
王羽
孔彭成
潘家坪
滕晓明
LIU Ya’nan;WANG Yu;KONG Pengcheng;PAN Jiaping;TENG Xiaoming(Reproductive Medicine Center,Shanghai First Maternity and Infant Hospital,Tongji University,Shanghai201202,China)
出处
《中国医药导报》
2021年第23期80-83,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81801538)。
关键词
非男性因素不孕
高龄女性
卵胞浆内单精子注射
Non-male factor infertility
Advanced maternal age
Intracytoplasmic sperm injection
