摘要
目的探讨输血治疗联合放化疗在结直肠癌患者中的疗效及对肿瘤标志物和T淋巴细胞水平的影响。方法回顾性分析2018年1月至2020年2月至云南省肿瘤医院接受治疗的结直肠癌患68例,结合患者病情,根据不同治疗方案均分为2组,对照组(n=34例)进行放化疗治疗,研究组(n=34例)进行输血治疗联合放化疗治疗。对比2组临床治疗效果、T淋巴细胞水平以及肿瘤标志物水平。结果研究组临床治疗有效率高于对照组,差异有统计学意义(P<0.05);干预前,2组T淋巴细胞因子水平对比,差异无统计学意义(P>0.05),治疗后,研究组CD8^(+)水平低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,差异有统计学意义(P<0.05);治疗前干预前,2组患者CA19-9、TK1、CEA、AFP水平比较,差异无统计学意义(P>0.05),治疗后,研究组CA19-9、TK1、CEA、AFP水平均低于对照组,差异有统计学意义(P<0.05)。结论结直肠癌患者施以输血治疗联合放化疗干预,可促进疗效提升,改善肿瘤标志物水平,提升机体免疫能力。
Objective To investigate the efficacy of blood transfusion combined with radiotherapy and chemotherapy in patients with colorectal cancer and its effects on tumor markers and T lymphocyte levels.Methods A retrospective analysis was performed on 68 patients with colorectal cancer who received treatment in Yunnan Cancer Hospital from January 2018 to February 2020.These patients were divided into 2 groups based on their conditions and treatment plans.The control group(34 cases)received radiotherapy and chemotherapy,and the study group(34 cases)received blood transfusion combined with radiotherapy and chemotherapy.The clinical therapeutic effect,T lymphocyte level and tumor marker level were compared between the two groups.Results The clinical effective rate of the study group was siginificantly higher than that of the control group(P<0.05).Before treatment,there was no statistically significant difference in the levels of T lymphocyte cytokines between the two groups(P>0.05).After treatment,the levels of CD8^(+)in the study group were lower than those in the control group,while the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were higher than those in the control group,with statistically significant differences(P>0.05).Before treatment,there were no statistically significant differences in the levels of CA19-9,TK1,CEA and AFP between 2 groups(P>0.05).After treatment,the levels of CA19-9,TK1,CEA and AFP in the study group were significantly lower than those in the control group(P<0.05).Conclusion Blood transfusion combined with radiotherapy and chemotherapy can improve the therapeutic effect,improve the level of tumor markers and enhance the immunity of colorectal cancer patients.
作者
王燕
丁荣
张吕玲
王若花
赵晓玲
马娜
WANG Yan;DING Rong;ZHANG Lvling;WANG Ruohua;ZHAO Xiaoling;MA Na(Dept.of Blood Transfusion,Yunnan Cancer Hospital,Kunming Yunnan 650118,China;Dept.of Interventional Radiology,Kunming Yunnan 650118,China)
出处
《昆明医科大学学报》
CAS
2022年第8期61-65,共5页
Journal of Kunming Medical University
基金
云南省科技厅-昆明医科大学联合专项基金资助项目(202101AY070001-166)。
关键词
输血治疗
放化疗
结直肠癌患者
疗效
肿瘤标志物
T淋巴细胞水平
Transfusion therapy
Radiotherary and chemotherapy
Colorectal cancer patients
Curative effect
Tumor markers
T lymphocyte level
