摘要
目的:分析结直肠癌根治术联合术中洛铂腹腔灌注化疗(IPC)的效果。方法:选取84例结直肠癌(CRC)患者,按照随机数字表法分为观察组和对照组,每组各42例。两组均行结直肠癌根治术治疗,对照组术中采用注入蒸馏水治疗,观察组术中采用洛铂IPC。比较两组血液及肝肾毒性、生存质量、肿瘤标志物、并发症及复发率。结果:观察组生存质量升高占比高于对照组,降低占比低于对照组(P<0.05),术后CA199、CEA、VEGF水平及复发率低于对照组(P<0.05);两组PLT、WBC计数及肝肾功能异常、总并发症发生率比较,差异无统计学意义(P>0.05)。结论:洛铂IPC用于结直肠癌根治术中在降低CA199、CEA、VEGF水平及复发率、提高生存质量方面更具优势,且手术并发症并未增加。
Objective:To study the effects of radical resection of colorectal cancer(CRC)combined with intraoperative intraperitoneal perfusion chemotherapy(IPC).Methods:A total of 84 CRC patients were selected and randomized into the observation group and control group,each with 42 cases.Both groups were treated with radical resection of colorectal cancer,then,the control group were treated with distilled water during the operation,and the observation group were treated with lobaplatin IPC during the operation.The blood,hepatorenal toxicity,quality of life,tumor markers,complications and recurrence rates were compared between the two groups.Results:The proportion of increased quality of life in the observation group was higher than that in the control group,and the proportion of decreased quality of life was lower than that in the control group(P<0.05);the postoperative CA199,CEA,VEGF levels and recurrence rate were lower than those in the control group,with statistical differences(P<0.05);and there were no significant differences in PLT,WBC,abnormal hepatorenal function and total complication rate between both groups(P>0.05).Conclusion:Loboplatin IPC has more advantages in reducing CA199,CEA,VEGF levels,recurrence rate,and improving quality of life during radical resection of colorectal cancer in patients and the surgical complications are not increased.
作者
张平峰
孙胜
ZHANG Pingfeng;SUN Sheng(The Affiliated Hospital of Jiujiang University,Jiujiang 332000,China)
出处
《华夏医学》
CAS
2022年第6期73-77,共5页
Acta Medicinae Sinica
基金
江西省卫生计生委科技计划项目(20197206)
关键词
结直肠癌根治术
洛铂
腹腔灌注化疗
生存质量
radical resection of colorectal cancer
lobaplatin
intraperitoneal perfusivn chemotherapy
quality of life
