摘要
乳腺癌中枢神经系统转移是乳腺癌患者死亡的主要原因之一。外周血循环肿瘤细胞(CTC)是肿瘤血行转移的“种子”,与乳腺癌中枢神经系统转移密切相关。CTC可通过分泌细胞因子适应肿瘤微环境及逃避免疫监视破坏血脑屏障等方式定植于中枢神经系统中。检测CTC分子的分型可能可预测中枢神经系统转移瘤的性激素受体及人类表皮生长因子受体的表达情况。乳腺癌CTC与中枢神经系统转移分子分型的差异研究可能可用于临床抗肿瘤治疗,有望为乳腺癌中枢神经转移患者提供精准的个体化治疗。该文主要从外周CTC与乳腺癌中枢神经系统转移的发生、发展进行综述。
Central nervous system metastasis of breast cancer is one of the main causes of death in the patients with breast cancer.Peripheral blood circulating tumor cell(CTC)is the“seed”of tumor hematogenous metastasis,which is closely related to the central nervous system metastasis of breast cancer.CTC can be colonized in the central nervous system by secreting the cytokines to adapt to tumor microenvironment,evading the immune surveillance and destroying the blood-brain barrier.Detecting the CTC molecular typing may be able to predict the expression of sex hormone receptor and human epidermal growth factor receptor in metastatic tumors of central nervous system.The study of difference between CTC and molecular typing of metastasis in central nervous system may be applied to clinical anti-tumor treatment,which is expected to provide the precise and individualized treatment for the patients with breast cancer complicating central nervous system metastasis.This article mainly reviews the occurrence and development of peripheral CTC and central nervous system metastasis of breast cancer.
作者
唐静(综述)
刘燕
农丽(审校)
TANG Jing;LIU Yan;NONG Li(Department of Breast and Bone Soft Tissue Tumor,Affiliated Tumor Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China)
出处
《重庆医学》
CAS
2022年第13期2321-2325,共5页
Chongqing medicine
基金
国家自然科学基金地区科学基金项目(81960477)
广西壮族自治区卫生健康委员会自筹经费课题(Z20170446)。
关键词
乳腺癌
中枢神经系统侵袭及转移
循环肿瘤细胞
综述
breast cancer
invasion and metastasis of central nervous system
CTC
review literature
