摘要
肿瘤血管和淋巴管生成是肿瘤生长、进展和转移的必要条件,且血管生成与肿瘤浸润免疫细胞息息相关。一方面,免疫细胞依赖于血管内皮细胞上的黏附分子而渗入肿瘤组织,并在其中表现出抗肿瘤的特性。另一方面,免疫细胞可以通过分泌趋化因子和细胞因子等多种途径调节肿瘤血管和淋巴管生成,因而其在肿瘤血行转移过程中起重要作用。此外,免疫细胞促肿瘤血行转移的作用凸显出了抗血管生成疗法的不足之处,所以就免疫细胞和血管新生之间的联系,同时靶向免疫细胞和肿瘤新生血管可以提高治疗效果。基于此,该文对肿瘤转移中免疫细胞对血管和淋巴管的作用以及相关免疫抗血管疗法进行综述,以期为后续研究提供参考。
Tumor blood and lymphatic vessel growth are necessary conditions for tumor growth,progression and metastasis,which are closely related with infiltrating innate as well as adaptive immune cells.On one hand,immune cells rely on adhesion molecules on vascular endothelial cells to penetrate into tumor tissues and show anti-tumor characteristics.On the other hand,they can regulate tumor angiogenesis and lymphangiogenesis by secreting chemokines and cytokines,playing an important role in the process of tumor blood metastasis.In addition,the role of immune cells in promoting tumor blood metastasis highlights the shortcomings of anti-angiogenic therapy.Therefore,targeting immune cells and tumor angiogenesis improve the effect of therapeutic.Based on these,this article summarizes the effects of immune cells on blood and lymphatic vessels in tumor metastasis,as well as related anti-vascular and immune therapies,in order to provide ideas for subsequent research.
作者
唐彧
郑维维
钱程
张珊
杨春媚
王飞辉
陆茵
王爱云
TANG Yu;ZHENG Wei-wei;QIAN Cheng;ZHANG Shan;YANG Chun-mei;WANG Fei-hui;LU Yin;WANG Ai-yun(Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2021年第12期1653-1658,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81973734)
江苏省中医药领军人才项目(No SLJ 0229)
江苏省研究生科研创新计划(No SJCX 20-0555)
全国中医药创新骨干人才培训项目(国中医药人教函【2019】128号文)
江苏省中药药效与安全性评价重点实验室开放课题(No JKLPSE201812)。
关键词
免疫细胞
肿瘤血管
肿瘤淋巴管
肿瘤血行转移
抗血管生成疗法
肿瘤免疫疗法
immune cells
tumor blood vessels
tumor lymphatic vessels
tumor blood metastasis
anti-angiogenic therapy
tumor immunotherapy
