摘要
目的采用基于静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)的局部一致性(regional homogeneity,ReHo)及功能连接算法探究终末期肾病(end-stage renal disease,ESRD)患者大脑神经元功能活动的变化,并分析其与血液生化指标之间的相关性。材料与方法前瞻性纳入36例ESRD患者以及32例健康对照者,所有受试者接受rs-fMRI扫描,计算全脑的ReHo值,选取ReHo值差异有统计学意义的脑区进行基于感兴趣区的功能连接分析。采用两独立样本t检验进行组间比较,并使用Pearson相关分析探讨ReHo值差异有统计学意义的脑区与实验室检查之间的相关性。结果与健康对照组相比,ERSD患者左侧颞极区、右眶部额下回、双侧直回的ReHo值显著升高(P<0.001,AlphaSim校正),双侧距状裂周围皮层、左侧额下回、右侧颞上回、右侧缘上回的ReHo值显著降低(P<0.001,AlphaSim校正);ERSD患者右侧距状裂周围皮层与左侧额下回、右侧缘上回的功能连接减弱,右侧缘上回与右侧颞上回的功能连接减弱(P<0.05,NBS校正)。ESRD患者右侧距状裂周围皮层ReHo值与血红蛋白水平及红细胞压积成正比(r=0.347,P=0.048;r=0.357,P=0.041)。结论ESRD患者在多个脑区存在局部功能活动同步性异常,主要累及默认模式网络,且在部分脑区表现出局部及远程大脑功能活动同步障碍,可能有助于进一步理解ESRD患者脑损伤的神经病理机制。
Objective:To investigate the alterations of neuronal functional activity in patients with end-stage renal disease(ESRD)by using regional homogeneity(Re Ho)and functional connectivity(FC)algorithm based on resting-state functional magnetic resonance imaging(rs-f MRI),and to analyze the association between spontaneous brain activity changes and blood biochemical index.Materials and Methods:Thirty-six patients with ESRD and 32 healthy controls were scanned with rs-f MRI to calculate the Re Ho value of the whole brain.Brain areas with altered Re Ho values were selected as regions of interest for FC analysis.Two independent sample t tests was used for comparison between groups,and Pearson’s correlation analysis was used between altered Re Ho values and blood biochemical index.Results:Compared with the healthy controls,ESRD patients showed the ReHo values in left temporal pole,right orbital inferior frontal gyrus and bilateral rectus gyrus were significantly increased(P<0.001,AlphaSim corrected),meanwhile,the ReHo values in bilateral calcarine sulcus,left inferior frontal gyrus,right superior temporal gyrus and supramarginal gyrus were significantly decreased(P<0.001,AlphaSim corrected).ESRD patients showed decreased FC between right calcarine sulcus and left inferior frontal gyrus and right supramarginal gyrus(P<0.05,NBS corrected).We also found decreased FC between right supramarginal gyrus and right superior temporal gyrus(P<0.01,NBS corrected).Correlation analyses showed that ReHo values in right calcarine sulcus were positively correlated with haemoglobin levels(r=0.347,P=0.048)and haematocrit(r=0.357,P=0.041).Conclusion:ESRD patients had dyssynchrony of local functional activities in several brain regions,mainly involving the default mode network,which may contribute to further understanding of the neuropathological mechanism of brain injury in ESRD patients.
作者
白迪
马驰
王成健
周彤
王家臣
毕玉珍
任延德
BAI Di;MA Chi;WANG Chengjian;ZHOU Tong;WANG Jiachen;BI Yuzhen;REN Yande(Department of Radiology,the Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Radiology,Qilu Hospital of Shandong University,Qingdao 266000,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第6期66-70,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
青岛市医药卫生科研计划项目(编号:2021-WJZD192)。
关键词
终末期肾病
静息态功能磁共振成像
脑损伤
局部一致性
功能连接
end-stage renal disease
resting-state functional magnetic resonance imaging
brain injury
regional homogeneity
functional connectivity
