摘要
目的 比较瑞马唑仑与丙泊酚在老年患者无痛胃镜中的镇静效果。方法 100例行无痛胃镜检查的老年患者,采用随机数字表法分为丙泊酚组(P组)和瑞马唑仑组(R组),每组50例。P组静脉推注丙泊酚+布托啡诺, R组静脉推注瑞马唑仑+布托啡诺。比较两组患者镇静起效时间、镇静成功率和苏醒时间,生命体征和不良反应发情况。结果 两组的镇静起效时间和镇静成功率比较差异无统计学意义(P>0.05);R组患者苏醒时间(8.02±1.32)min短于P组的(12.63±1.27)min,差异有统计学意义(P<0.05)。R组41例患者在操作过程中平均动脉压下降在基础压值10%以内, 9例在20%以内,均不需要升压药物处理;P组18例患者在操作过程中平均动脉压下降在基础压值10%以内, 24例在20%以内,其余8例因血压过低需要多巴胺升压处理;两组平均动脉压下降情况比较差异具有统计学意义(P<0.05)。R组的低血压、低氧血症、注射痛和头晕发生率分别为0、0、0、14%,均显著低于P组的16%、18%、48%、40%,差异有统计学意义(P<0.05);两组心动过缓及恶心呕吐发生率比较差异无统计学意义(P>0.05)。结论 在老年患者的无痛胃镜检查中,瑞马唑仑比丙泊酚生命体征更平稳,苏醒快,不良反应少。
Objective To compare the sedative effects of remimazolam and propofol in painless gastroscopy in elderly patients.Methods A total of 100 elderly patients undergoing painless gastroscopy were randomly divided into propofol group(P group)and remimazolam group(R group),with 50 cases in each group.P group was injected with propofol+butorphanol,and R group was injected with remimazolam+butorphanol.The onset time of sedation,success rate,recovery time,vital signs,and occurrence of adverse reactions were compared between the two groups.Results There was no statistically significant difference in the onset time of sedation and the success rate of sedation between the two groups(P>0.05).The recovery time(8.02±1.32)min in R group was shorter than(12.63±1.27)min in P group,and the difference was statistically significant(P<0.05).In R group,the mean arterial pressure decreased within 10%of the basal pressure value during the surgery in 41 patients,and within 20%in 9 cases,all of whom did not require blood pressure-raising medication.In P group,the mean arterial pressure decreased within 10%of the basal pressure in 18 patients and within 20%in 24 patients during the surgery,and the remaining 8 patients required dobutamine for hypotension.There was statistically significant difference in the decrease of mean arterial pressure between the two groups(P<0.05).The incidence rates of hypotension,hypoxemia,injection pain and dizziness in R group were 0,0,0,and 14%,which were significantly lower than 16%,18%,48%,and 40%in P group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of bradycardia and nausea and vomiting between the two groups(P>0.05).Conclusion During the painless gastroscopy in elderly patients,remimazolam has more stable vital signs,faster recovery,and fewer adverse reactions than propofol.
作者
程晓辉
齐丽君
屈常伟
杨中贞
赵峰
CHENG Xiao-hui;QI Li-jun;QU Chang-wei(Department of Anesthesiology,Heze Municiple Hospital,Heze 274031,China)
出处
《中国实用医药》
2022年第13期12-15,共4页
China Practical Medicine
关键词
瑞马唑仑
丙泊酚
胃镜检查
静脉麻醉
Remimazolam
Propofol
Gastroscopy
Intravenous anesthesia
