摘要
目的探讨血清脑源性神经营养因子(BDNF)、神经生长因子(NGF)、髓鞘碱性蛋白(MBP)在青少年精神分裂症患者中的表达水平及其对预后评估的价值。方法选取120例青少年精神分裂症患者为观察组,使用二代非典型抗精神病药物治疗,分别于治疗前、治疗后及随访1年后进行阳性和阴性精神症状评定量表(PANSS)评分。采用ELISA法检测血清BDNF、NGF、MBP水平,并以同期健康体检的120例青少年为对照组进行对比分析。结果治疗前,观察组血清BDNF、NGF水平低于对照组,MBP水平高于对照组(P<0.05);治疗后和随访1年后,观察组血清BDNF和NGF水平升高,MBP水平和PANSS评分降低(P<0.05)。血清BDNF、NGF水平与PANSS评分呈负相关(P<0.05),MBP水平与PANSS评分呈正相关(P<0.05)。血清BDNF、NGF和MBP联合预测青少年精神分裂症预后的AUC值为0.866。结论血清BDNF、NGF、MBP水平与青少年精神分裂患者病情具有显著的相关性,可以作为患者预后评价的诊断指标。
Aim To investigate the expression levels and prognostic value of serum brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)and myelin basic protein(MBP)in adolescent patients.Methods A total of 120 adolescents with schizophrenia were selected as the observation group,which were all treated with second-generation atypical antipsychotic drugs.The positive and negative syndrome scale(PANSS)score was performed before treatment,after treatment and 1 year after follow-up.Serum levels of BDNF,NGF and MBP were detected by ELISA assay.At the same time,a total of 120 healthy adolescents underwent physical examination at the same time were compared and analyzed as the control group.Results Before treatment,the levels of serum BDNF and NGF were lower while MBP was higher in the observation group than those in the control group(P<0.05).After treatment and 1 year after follow-up,the serum levels of BDNF and NGF were increased while MBP and PANSS were decreased in the observation group(P<0.05).Serum BDNF and NGF levels were negatively correlated with PANSS score(P<0.05),while MBP level was positively correlated with PANSS score(P<0.05).The AUC value of serum BDNF,NGF and MBP combined to predict the prognosis of adolescent schizophrenia was 0.866.Conclusion Serum BDNF,NGF,MBP levels have significant correlation with the condition of adolescent schizophrenia patients,and can be used as diagnostic indicators for prognosis evaluation of patients.
作者
黎顺成
徐雪怡
陈程
刘向来
LI Shuncheng;XU Xueyi;CHEN Cheng;LIU Xianglai(The Fifth Department of Psychiatry,the Fourth People's Hospital of Hainan,Haikou 570206,Hainan,China;Department of Medical Rehabilitation,the Fourth People's Hospital of Hainan,Haikou 570206,Hainan,China;Institute of Psychiatry,the Fourth People's Hospital of Hainan,Haikou 570206,Hainan,China)
出处
《中南医学科学杂志》
CAS
2022年第4期528-531,共4页
Medical Science Journal of Central South China
基金
海南省自然科学基金面上项目(819MS129)。
