摘要
目的探讨首发精神分裂症患者的血清S100B蛋白水平与精神分裂症及其认知功能的关系。方法纳入符合美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)精神分裂症诊断标准的首发精神分裂症患者(以下简称患者组)40例和正常对照者(以下简称对照组)40例,检测血清S100B蛋白水平,同时应用阳性和阴性症状量表(PANSS)和威斯康星卡片分类测验(WCST)韦氏记忆量表(WMS)评定患者的病情和认知功能,并进行两组间比较。结果患者组血清S100B蛋白水平明显高于对照组(P<0.001)。患者组WCST的完成分类数得分低于对照组(P=0.004),而错误应答数、完成第一个分类所需应答数、持续性错误数、持续性应答和持续性错误百分数均高于对照组(P值均<0.05),患者组WMS的长时记忆、短时记忆、瞬时记忆和记忆商数均低于对照组(P<0.001)。患者组血清S100B蛋白水平与PANSS的总分、阴性症状分呈正相关(r分别为0.317、0.405,P均<0.05),与WCST中的错误应答数、持续性应答及非持续性错误数呈正相关(r分别为0.393、0.359和0.378,P均<0.05),与WMS中的短时记忆呈负相关(r为-0.320,P<0.05)。结论首发精神分裂症患者血清S100B蛋白水平明显高于正常,其水平升高越明显,表明精神分裂症的严重程度和认知损害程度就越重。
Objective To discuss the relation between level of serum S100B protein and recognition function of primary schizophrene patient. Methods 40 cases of such patient who were diagnosed according to American Standard and DSM - Ⅳ and other 40 cases of healthy adult were detected with level of S100B protein. The PANSS, WCST and WMS were used to detect the recognition function of patient in control group and patient group. Results The S100B protein level in patient group was higher than that of control group P 〈 0.01. The WCST in patient group was lower than that of control group P 〈 0.05. The misresponds, contineous mistake number, contineous responds number and contineous mistakes in patient group were higher than those in control group. The longterm memory, shorterm memory, instant memory and memory index in patient group of WMS were lower than those in congtrol group. The level of S100B protein was positive with PANSS total score, negative symptoms and most WCS but negative with shorterm memory. Condusion The level of S100B protein in patient group was higher than that in congtrol group and positive relationship with degree of Prirrkary Schizophrene and recognition.
出处
《黑龙江医学》
2008年第9期649-650,670,共3页
Heilongjiang Medical Journal
