摘要
目的:探究慢性肾脏病(CKD)患者肾功能分期、血清胱抑素C(CystC)及生命质量与睡眠呼吸障碍(SDB)的相关性。方法:选取2019年5月至2021年2月雷州市人民医院收治的CKD患者134例,分析CKD患者肾功能分期、CystC及生命质量与SDB的相关性。结果:CKD5期患者血清CystC水平、Epworth嗜睡量表(ESS)评分、日间嗜睡过多(EDS)发生率及睡眠呼吸相关指标水平均高于CKD1~2期与CKD3~4期,而QOL评分低于CKD1~2期与CKD3~4期(均P<0.05);CKD肾功能分期、血清CystC与SDB指标[ESS评分、呼吸暂停低通气指数(AHI)≥15次/h、低通气指数、夜间低氧血症发生率]正相关(均P<0.05);CKD患者生命质量(QOL)评分与SDB相关指标(ESS评分、AHI≥15次/h、低通气指数、夜间低氧血症发生率)负相关(均P<0.05)。结论:多数CKD患者伴有SDB,且随肾功能降低、血清CystC增加SDB患病风险增加,生命质量及睡眠质量下降,伴有日间嗜睡症状。
Objective:To investigate the correlation between renal function stage,serum cystatin C(CystC),quality of life and sleep disordered breathing(SDB)in patients with chronic kidney disease(CKD).Methods:A total of 134 cases of patients with CKD were collected to analyze the correlation between SDB and renal function stage,CystC and quality of life in CKD patients.Results:The levels of serum CystC,Epworth Sleepiness Scale(ESS)score,excessive daytime sleepiness(EDS)incidence and sleep-respiratory indexes in CKD5 patients were higher than those in CKD1~2 and CKD3~4,while the Quality of Life(QOL)score was lower than those in CKD1~2 and CKD3~4(Ps<0.05).Renal function stage of CKD,serum CystC and SDB indicators(ESS score,AHI≥15 times/h,hypoventilation index,nocturnal hypoxemia incidence)were positively correlated(Ps<0.05).QOL score of CKD patients was negatively correlated with SDB indicators[ESS score,Apnea Hypopnea Index(AHI)≥15 times/h,hypoventilation index,nocturnal hypoxemia incidence](Ps<0.05).Conclusion:Most CKD patients are associated with SDB,and the risk of SDB increases with the decrease of renal function and the increase of serum CystC,and the decrease of life quality and sleep quality,accompanied by daytime sleepiness.
作者
邓祖抚
DENG Zufu(Department of Nephrology,Leizhou People′s Hospital,Leizhou 524200,China)
出处
《世界睡眠医学杂志》
2022年第4期633-635,共3页
World Journal of Sleep Medicine
关键词
慢性肾脏病
睡眠呼吸障碍
肾功能分期
血清胱抑素C
生命质量
Chronic kidney disease
Sleep disordered breathing
Renal function stage
Serum cystatin C
Quality of life
