摘要
目的:观察中原门氏验方——消癥煎治疗特发性畸形精子症不育(湿热瘀结证)患者的临床疗效。方法:100例特发性畸形精子症不育(湿热瘀结证)患者按来院就诊时间的先后顺序,按照随机数字表法随机(11)均分为试验组(消癥煎)、对照组(左卡尼汀口服液)各50例。治疗12周后,比较患者配偶妊娠率,精子形态学参数(正常形态精子率、头部畸形精子率),前向运动精子活力、精子总活力和精子顶体酶活性,中医证候积分。结果:试验组有效率为82.61%,对照组有效率为71.11%,两组有效率比较,差异有统计学意义(χ^(2)=8.417,P=0.038);两组临床等级疗效经秩和检验,差异有统计学意义(z=-2.563,P=0.010)。治疗后,试验组中14例患者配偶妊娠,妊娠率为29.79%;对照组中6例患者配偶妊娠,妊娠率为12.50%,两组配偶妊娠率比较,差异有统计学意义(P<0.05)。与治疗前比较,两组患者正常形态精子率、前向运动精子活力、精子总活力和精子顶体酶活性显著升高(P<0.05),试验组以上指标高于同期对照组(P<0.05)。与治疗前比较,两组患者精子头部畸形率、中医证候积分显著降低(P<0.05),试验组精子头部畸形率、中医证候积分低于同期对照组(P<0.05)。结论:消癥煎治疗湿热瘀结型特发性畸形精子症疗效显著,可降低精子头部畸形率,提高配偶妊娠率,并能改善前向运动精子活力、精子总活力、顶体酶活性及中医临床症状。
Objective:To observe the clinical effect of Zhongyuanmen′s prescription-Xiaozheng Decoction in treatment of infertility of idiopathic teratozoospermia(Damp-Heat stagnation syndrome).Methods:100 cases of infertility patients with idiopathic teratozoospermia(damp-heat stasis syndrome) were listed in the order of the time of visiting the hospital,and according to the random number table method,were randomly divided into the experimental group(Xiaozheng Decoction) and the control group(L-carnitine oral liquid),with 50 cases in each group.After 12 weeks of treatment,the patients′ spouse pregnancy rate,sperm morphology parameters(normal shape sperm rate,head deformity sperm rate),forward motility sperm motility,total sperm motility,sperm acrosome enzyme activity,and TCM syndrome scores were compared.Results:The effective rate of the experimental group was 82.61%,and the effective rate of the control group was 71.11%,and the difference was statistically significant(χ^(2)=8.417,P=0.038).The clinical grade efficacy of the two groups was tested by the rank-sum test,and the difference was statistically significant(z=-2.563,P=0.010).After treatment,the spouses of 14 patients were pregnant,and the pregnancy rate was 29.79%.In the control group,the spouses of 6 patients were pregnant,the pregnancy rate was 12.50%,and the difference was statistically significant between the two groups(P<0.05).Compared with before treatment,the normal morphology sperm rate,forward motility sperm motility,total sperm motility,and sperm acrosome enzyme activity in the two groups were significantly increased(P<0.05),and the above indexes in the experimental group were higher than those in the control group(P<0.05).Compared with before treatment,the sperm head deformity rate and TCM syndrome scores in the two groups were significantly decreased(P<0.05),and the sperm head deformity rate and TCM syndrome scores in the experimental group were lower than those in the control group(P<0.05).Conclusion:Xiaozheng Decoction has a significant curative ef
作者
门波
付晓君
王程阁
陈建设
张华
张辉
MEN Bo;FU Xiaojun;WANG Chengge;CHEN Jianshe;ZHANG Hua;ZHANG Hui(The Second Affiliated Hospital of Henan University of Chinese Medicine/Henan Province Hospital of Chinese Medicine,Zhengzhou Henan China 450002)
出处
《中医学报》
CAS
2022年第8期1760-1764,共5页
Acta Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2019ZY2020)。
关键词
特发性畸形精子症
不育症
消癥煎
湿热瘀结证
精子形态学
前向运动精子活力
精子总活力
精子顶体酶活性
idiopathic teratozoospermia
infertility
Xiaozheng Decoction
Damp-Heat stagnation syndrome
sperm morphology
forward motility sperm motility
total sperm motility
sperm acrosome enzyme activity
