摘要
目的探讨银杏蜜环口服溶液联合氟哌噻吨美利曲辛(黛力新)治疗缺血性脑卒中后抑郁的临床效果。方法选取2019年1月至2020年2月赣南医学院第二附属医院神经内科收治的100例缺血性脑卒中后轻、中度抑郁患者作为研究对象,采用随机数字奇偶法将其分为两组,每组各50例。两组患者均予常规的治疗措施和必要的康复治疗,对照组在常规治疗基础上服用氟哌噻吨美利曲辛,试验组在常规治疗基础上服用氟哌噻吨美利曲辛联合银杏蜜环口服溶液。两组患者均连续用药4周。比较两组患者治疗前后的汉密尔顿抑郁量表(HAMD)评分和日常生活活动能力指数(BI);比较两组患者的临床疗效;比较两组患者的不良反应发生情况。结果两组患者治疗后的HAMD评分均低于治疗前,BI评分均高于治疗前,差异有统计学意义(P<0.05);治疗后,试验组患者的HAMD评分低于对照组,BI评分高于对照组,差异有统计学意义(P<0.05);试验组患者的总有效率(90.00%)高于对照组(74.00%),差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论银杏蜜环口服溶液联合氟哌噻吨美利曲辛治疗缺血性脑卒中后抑郁的效果优于单用氟哌噻吨美利曲辛,能改善患者4周时的日常生活活动能力和抑郁症状。
Objective To investigate the clinical efficacy of Ginkgo Armillaria Oral Solution combined with Flupentixol and Melitracen in the treatment of post ischemic stroke depression.Methods A total of 100 patients with mild to moderate post ischemic stroke depression admitted to the Department of Neurology in the Second Affiliated Hospital of Gannan Medical University from January 2019 to February 2020 were selected as subjects.They were divided into two groups with 50 cases in each group by random number parity method.The patients in the two groups were given routine treatment and necessary rehabilitation treatment.The control group was treated with Flupentixol and Melitracen on the basis of routine treatment,and the experimental group was treated with Flupentixol and Melitracen and Ginkgo Armillaria Oral Solution on the basis of routine treatment.The patients in the two groups were treated continuously for 4 weeks.Hamilton depression scale(HAMD)score and Barthel index(BI)were compared between the two groups before and after treatment.The clinical efficacy of the two groups was compared.The incidence of adverse reactions was compared between the two groups.Results The HAMD scores of the two groups after treatment were lower than those before treatment,BI scores of the two groups after treatment were higher than those before treatment,the differences were statistically significant(P<0.05).After treatment,HAMD score of experimental group was lower than that of control group,BI score was higher than that of control group,the differences were statistically significant(P<0.05).The total effective rate of experimental group(90.00%)was higher than that of control group(74.00%),and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The effect of Ginkgo Armillaria Oral Solution combined with Flupentixol and Melitracen in the treatment of post ischemic stroke depression is better than that of Flupentixol an
作者
肖丽春
蔡俊
吴海平
朱明光
唐玉英
田克瑶
谢东阳
XIAO Lichun;CAI Jun;WU Haiping;ZHU Mingguang;TANG Yuying;TIAN Keyao;XIE Dongyang(Department of Neurology,the Second Affiliated Hospital of Gannan Medical University,Jiangxi Province,Ganzhou341000,China;Graduate School of Gannan Medical University,Jiangxi Province,Ganzhou341000,China;Department of Cardiovascular Medicine,the Second Affiliated Hospital of Gannan Medical University,Jiangxi Province,Ganzhou341000,China)
出处
《中国当代医药》
CAS
2022年第13期58-61,65,共5页
China Modern Medicine
基金
江西省赣州市指导性科技计划项目(GZ2018ZSF 125)。
关键词
银杏蜜环口服溶液
氟哌噻吨美利曲辛
缺血性脑卒中后抑郁
治疗效果
Ginkgo Armillaria Oral Solution
Flupentixol and Melitracen
Post ischemic stroke depression
Therapeutic effect
