摘要
目的比较立体定向体部放疗(SBRT)或胰十二指肠切除术(PD)联合化疗与单独化疗治疗Ⅰ/Ⅱ期胰腺癌患者的效果。方法分析赣南医学院附属萍乡医院2010年1月至2017年2月间Ⅰ/Ⅱ期胰腺癌患者172例,分为4组:A组(保守)、B组(化疗)、C组(SBRT+化疗)和D组(PD+化疗),分析四组疼痛评分、缓解情况、中位无进展生存时间、中位生存时间、生存率、不良反应及并发症发生率。结果与A组比较,B组、C组、D组疼痛评分和疾病进展率显著降低,部分缓解率、疾病稳定率、临床收益率、总疗效率、中位无进展生存时间、中位生存时间、生存率和不良反应发生率均显著升高;与B组比较,C组或D组治疗后的疼痛评分、疾病进展率和复发率降低、完全缓解率、临床收益率、总疗效率、中位无进展生存时间和中位生存时间、生存率和不良反应发生率均显著升高;D组与C组疼痛评分比较,差异无统计学意义(P>0.05),疾病进展率显著性降低,治疗后的完全缓解率、临床收益率和总疗效率显著升高,中位无进展生存时间、中位生存时间和生存率比较,差异无统计学意义(P>0.05),复发率、不良反应和并发症发生率显著降低。结论SBRT或PD联合化疗与单一化疗均能有效治疗Ⅰ/Ⅱ期胰腺癌,联合治疗较单一化疗好,PD+化疗组复发率、不良反应和并发症发生率少于SBRT+化疗组。
Objective To compare the efficacies of stereotactic body radiotherapy(SBRT)or pancreatoduodenectomy(PD)combined with chemotherapy and chemotherapy alone in the treatment of patients with stageⅠ/Ⅱpancreatic cancer.Methods A total of 172 patients with stageⅠ/Ⅱpancreatic cancer treated in Pingxiang Hospital Affiliated to Gannan Medical University from January 2010 to February 2017 were divided into four groups as the group A(conservative),the group B(chemotherapy),the group C(SBRT combined with chemotherapy)and the group D(PD combined with chemotherapy).The pain score,relief status,median progression-free survival time,median survival time,survival rate,side effects and incidence of complications were compared among the four groups.Results Compared with the group A,the pain scores and disease progression rates in the group B,C and D were significantly reduced,and the partial remission rates,disease stability rates,clinical return rates,total treatment efficacies,median progression-free survival time,median survival time,survival rates,and incidences of side effects significantly increased.Compared with the group B,the pain scores,disease progression rates and recurrence rates in the group C and D decreased after treatment,and the complete remission rates,clinical return rates,total treatment efficacies,median progression-free survival time,median survival time,survival rates and incidences of side effects significantly increased.There was no statistically significant difference in the pain score between the group C and the group D.Compared with the group C,the disease progression rate in group D was significantly reduced,and the complete remission rate,clinical return rate and total treatment efficiency significantly increased.There were no statistically significant differences in median progression-free survival time,median survival time and survival rate between the two groups.Compared with the group C, the recurrence rate,side effects and incidence of complications in the group D were significantly reduce
作者
和庆章
徐卉卉
王桂良
邱萍
徐林芳
龚敏
韩明
文剑波
HE Qingzhang;XU Huihui;WANG Guiliang;QIU Ping;XU Linfang;GONG Min;HAN Ming;WEN Jianbo(Department of Gastroenterology,Pingxiang Hospital Affiliated to Gannan Medical University,Pingxiang 337000,China;Department of Oncology,Zhuzhou Second Hospital in Hunan Province,Zhuzhou 412000,China)
出处
《中国现代医生》
2022年第11期20-24,共5页
China Modern Doctor
关键词
胰腺癌
化疗
立体定向体部放疗
胰十二指肠切除术
Pancreatic cancer
Chemotherapy
Stereotactic body SBRT
Pancreaticoduo-denectomy
