摘要
目的:探究血清脂蛋白[Lp(a)]、载脂蛋白(ApoA)、胱抑素(CysC)、高敏C反应蛋白(hs-CRP)水平与非ST段抬高型急性冠状动脉综合征(NSTE-ACS)患者病情程度的相关性。方法:选取某院2019年1月~2021年6月NSTE-ACS患者39例设为研究组,另选同期STE-ACS患者38例设为对照组,均行血清Lp(a)、ApoA、CysC、hs-CRP水平检测,比较研究组与对照组血清Lp(a)、ApoA、CysC、hs-CRP水平,对比不同病情程度NSTE-ACS患者血清Lp(a)、ApoA、CysC、hs-CRP水平,分析血清Lp(a)、ApoA、CysC、hs-CRP水平与NSTE-ACS患者病情程度的相关性。结果:研究组血清Lp(a)、CysC、hs-CRP水平高于对照组,血清ApoA水平低于对照组(P<0.05);不同病情程度NSTE-ACS患者血清Lp(a)、ApoA、CysC、hs-CRP水平比较,差异显著(P<0.05),且重度患者血清Lp(a)、CysC、hs-CRP水平高于轻中度患者,血清ApoA水平低于轻中度患者(P<0.05);血清Lp(a)、CysC、hs-CRP水平与NSTE-ACS患者病情程度呈正相关(P<0.05),血清ApoA水平与NSTE-ACS患者病情程度呈负相关(P<0.05)。结论:NSTE-ACS患者血清Lp(a)、CysC、hs-CRP水平呈异常高表达,血清ApoA水平呈异常低表达,血清Lp(a)、ApoA、CysC、hs-CRP水平与NSTE-ACS患者病情程度呈显著相关性,其水平检测有助于评估NSTE-ACS患者病情程度。
Objective:To explore the correlation between serum lipoprotein[Lp(a)],apolipoprotein(ApoA),cystatin(CysC),high sensitive C reactive protein(hs-CRP)and the disease degree of patients with non ST elevation acute coronary syndrome(NSTE-ACS).Methods:39 cases of NSTE-ACS patients in a hospital from January 2019 to June 2021 were selected as the study group,and 38 cases of STE-ACS patients were selected as the control group at the same time.The serum levels of Lp(a),ApoA,CysC and hs-CRP were measured,the serum levels of Lp(a),ApoA,CysC and hs-CRP were compared between the study group and the control group,the serum levels of Lp(a),ApoA,CysC and hs-CRP in NSTE-ACS patients with different degrees of disease were compared,and the correlation between serum Lp(a),ApoA,CysC and hs-CRP levels and the degree of disease condition of NSTE-ACS patients were analyzed.Results:The serum levels of Lp(a),CysC and hs-CRP in the study group were higher than those in the control group,and the serum ApoA level was lower than that in the control group(P<0.05).There were significant differences in serum Lp(a),ApoA,CysC and hs-CRP levels in NSTE-ACS patients with different degrees of disease(P<0.05).The serum levels of Lp(a),CysC and hs-CRP in severe patients were higher than those in mild or moderate patients,and serum ApoA level was lower than that of mild to moderate patients(P<0.05).Serum Lp(a),CysC and hs-CRP levels were positively correlated with the degree of disease of NSTE-ACS patients(P<0.05).Serum ApoA level was negatively correlated with the degree of disease of NSTE-ACS patients(P<0.05).Conclusion:The levels of serum Lp(a),CysC and hs-CRP in NSTE-ACS patients show abnormally high expression,and the serum ApoA level shows abnormally low expression.The levels of serum Lp(a),ApoA,CysC and hs-CRP are significantly correlated with the degree of disease of NSTE-ACS patients,and the serum levels detection is helpful to evaluate the degree of NSTE-ACS patients.
作者
范少华
Fan Shaohua(Department of Clinical Laboratory,Beijing Fengtai Hospital of Integrated Traditional Chinese and Western Medicine Laboratory,Beijing 100072)
出处
《数理医药学杂志》
CAS
2022年第6期799-802,共4页
Journal of Mathematical Medicine
