摘要
目的:探讨非ST段抬高型急性冠脉综合征(NSTE-ACS)患者平均血小板体积(MPV)、血小板分布宽度(PDW)及胱抑素C(CysC)与全球急性冠状动脉事件注册(GRACE)评分的相关性。方法:选择我院就诊的269例NSTE-ACS患者(NSTE-ACS组)及同期73例非冠心病患者(非CHD组),检测两组血MPV、PDW及CysC水平,并进行GRACE危险评分,比较各亚组检测指标水平,分析其与GRACE评分相关性。结果:与非CHD组比较,NSTE-ACS组MPV、PDW和CysC水平均显著升高(P均=0.001)。NSTE-ACS患者按GRACE评分增加程度分为低危(76例)、中危(144例)、高危(49例),低危、中危、高危患者MPV[(10.09±0.79)fl比(10.74±0.68)fl比(11.32±0.85)fl]、PDW[(11.19±1.31)%比(13.52±2.14)%比(15.06±1.70)%]和CysC[(0.79±0.14)mg/L比(0.82±0.16)mg/L比(0.86±0.2)mg/L]水平均依次显著升高(P均=0.001);Speaman相关分析显示,GRACE评分与MPV、PDW和CysC水平均呈显著正相关(r=0.767,0.813,0.738,P均=0.001)。结论:平均血小板体积、血小板分布宽度、胱抑素C与GRACE评分密切相关,对NSTE-ACS患者早期危险分层及预后评估有重要指导价值。
Objective:To explore correlation among mean platelet volume(MPV),platelet distribution width(PDW),cystatin C(CysC)and Global Registry of Acute Coronary Events(GRACE)score in patients with non-ST segment elevation-acute coronary syndrome(NSTE-ACS).Methods:A total of 269 NSTE-ACS patients(NSTE-ACS group)and 73 simultaneous non CHD patients(non-CHD group)treated in our hospital were enrolled.Blood levels of MPV,PDW and CysC were measured in two groups,and GRACE score was assessed,then above index levels were measured and compared among all subgroups,and their correlations with GRACE score were analyzed.Results:Compared with non-CHD group,there were significant rise in levels of MPV,PDW and CysC in NSTE-ACS group,P=0.001 all.NSTE-ACS patients were divided into low risk(76 cases),medium risk(144 cases),and high risk(49 cases)according to the increase degree of GRACE score.For low risk,medium risk,high risk patients,the levels of MPV[(10.09±0.79)fl vs.(10.74±0.68)fl vs.(11.32±0.85)fl],PDW[(11.19±1.31)%vs.(13.52±2.14)%vs.(15.06±1.70)%]and CysC[(0.79±0.14)mg/L vs.(0.82±0.16)mg/L vs.(0.86±0.2)mg/L]significantly rise in turn,P=0.001 all.Spearman correlation analysis indicated that GRACE score was significant positively correlated with MPV,PDW and CysC level(r=0.767,0.813,0.738,P=0.001 all).Conclusion:Mean platelet volume,platelet distribution width,and cystatin C are closely related to GRACE score,and it possesses important guidance value for early risk stratification and prognosis evaluation in NSTE-ACS patients.
作者
周凡凡
夏勇
ZHOU Fan-fan;XIA Yong(Department of Cardiology,Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu,221000,China)
出处
《心血管康复医学杂志》
CAS
2021年第2期136-140,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
