摘要
目的 观察加味四妙勇安汤治疗湿热蕴结型急性痛风性关节炎的疗效。方法 回顾性分析2017年10月至2020年11月杭州市萧山区中医院收治的76例急性痛风性关节炎患者为研究对象,根据治疗方案不同分为观察组和对照组,每组38例。对照组口服依托考昔片治疗,观察组在对照组基础上应用加味四妙勇安汤口服治疗,两组均治疗2周。比较治疗前后症状评分、生化指标、炎症指标、临床疗效及不良反应。结果 治疗后两组VAS疼痛评分及关节肿胀评分与治疗前比较均明显下降(P<0.05),且观察组低于对照组(P<0.05)。治疗后两组ESR、UA、Cr水平较治疗前均明显下降(P<0.05),且观察组ESR、UA、Cr水平显著低于对照组(P<0.05);但两组治疗前后ALT水平比较,差异无统计学意义(P>0.05)。两组治疗后CRP、TNF-α、IL-1β水平较治疗前均明显下降,差异有统计学意义(P<0.05),且观察组显著低于对照组(P<0.05)。观察组优良率(89.47%)高于对照组(65.79%)(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 加味四妙勇安汤能有效减轻湿热蕴结型痛风性关节炎患者的临床症状,降低炎症指标,提高临床疗效,适宜临床推广应用。
Objective To observe the efficacy of modified Simiao Yong’an decoction in the treatment of acute gouty arthritis of damp-heat accumulation type. Methods A total of 76 patients with acute gouty arthritis admitted to Xiaoshan Hospital of Traditional Chinese Medicine in Hangzhou City from October 2017 to November 2020 were selected as study subjects and retrospectively analyzed. They were divided into the observation group and the control group according to different treatment regimens, with 38 cases in each group. The control group was treated with oral etoricoxib tablets, while the observation group was treated with modified Simiao Yong’an decoction orally on the basis of treatment in the control group, and both groups were treated for 2 weeks. The symptom scores, biochemical indicators, inflammation indicators, clinical efficacy and adverse reactions before and after treatment were compared between the two groups. Results After treatment, the Visual Analogue Scale(VAS) score and joint swelling score in both groups were significantly lower than those before treatment, with statistically significant differences(P<0.05), and those in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05).After treatment, the levels of erythrocyte sedimentation rate(ESR), uric acid(UA) and creatinine(Cr) in both groups were significantly lower than those before treatment, with statistically significant differences(P<0.05), and those in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). However, there was no statistically significant difference between the two groups in the level of alanine transaminase(ALT) before and after treatment(P>0.05). After treatment, the levels of C-reactive protein(CRP), tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in both groups were significantly lower than those before treatment, with statistically significant differences(P<0.05),
作者
汤样华
李宝萍
莫亚峰
李永福
TANG Yanghua;LI Baoping;MO Yafeng;LI Yongfu(Department of Orthopedics,Xiaoshan Hospital of Traditional Chinese Medicine in Hangzhou City,Hangzhou 311201,China;Department of Orthopedics,the Second People′s Hospital of Tonglu County in Hangzhou City,Zhejiang,Hangzhou 311519,China)
出处
《中国现代医生》
2022年第15期148-151,共4页
China Modern Doctor
基金
浙江省中医药“新苗”计划项目(浙中医药[2021]1号)。
关键词
四妙勇安汤
湿热蕴结型
急性痛风性关节炎
痹症
Simiao Yong’an decoction
Damp-heat accumulation type
Acute gouty arthritis
Paralysis
