摘要
目的探讨与分析三种不同血液净化模式对慢性肾功能衰竭尿毒症患者肾功能指标、营养状况的影响,同时观察不同血液净化方式应用期间的不良反应。方法选取2018年4月至2021年4月辽宁省辽阳市中心医院收治的120例慢性肾功能衰竭尿毒症患者作为研究对象,采取随机数字表法将其分为A组(n=40)、B组(n=40)、C组(n=40)。A组患者给予常规血液透析治疗,B组患者给予给予高通量血液透析治疗,C组患者给予血液透析滤过治疗。比较三组患者的肾功能指标、营养状况指标水平,同时观察治疗期间的不良反应发生情况。结果三组患者治疗后的红细胞沉降率(ESR)、尿蛋白、血肌酐(SCr)水平低于本组治疗前,血尿素氮(BUN)水平高于本组治疗前,B组患者的ESR、尿蛋白、SCr水平低于A组及C组,BUN水平高于A组及C组,A组患者的ESR、尿蛋白、SCr、BUN水平高于C组,差异有统计学意义(P<0.05)。三组患者治疗后的总蛋白(TP)、白蛋白(ALB)、前白蛋白(PA)及血红蛋白(Hb)水平均高于本组治疗前,B组患者的TP、ALB、PA及Hb水平高于A组及C组,差异有统计学意义(P<0.05)。三组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论高通量血液透析治疗慢性肾功能衰竭尿毒症的效果,要明显优于常规血液透析治疗以及血液透析滤过治疗,不仅能够有效促进和改善患者的肾功能指标,同时帮助改善患者的营养状况,且治疗期间未增加不良反应,安全性较高。
Objective To explore and analyze the effect of three different blood purification modes on the renal function indexes and nutritional status of patients with chronic renal failure and uremia,and to observe the adverse reactions during the application of different blood purification methods.Methods A total of 120 patients with chronic renal failure and uremia admitted to Liaoyang Central Hospital in Liaoning Province from April 2018 to April 2021 were selected as the research objects.The random number table method was used to divide them into group A with 40 cases,group B with 40 cases,and group C with 40 cases.Group A was given conventional hemodialysis treatment,group B was given high-flux hemodialysis treatment,group C was given hemodiafiltration treatment.The renal function indexes and nutrition-related indexes of patients of the three groups were compared,and the adverse reactions during the treatment period were observed.Results The levels of erythrocyte sedimentation rate(ESR),urine protein,and serum creatinine(SCr)after treatment in the three groups were lower than those before treatment,the blood urea nitrogen(BUN)levels in the three groups were higher than those before treatment,the levels of ESR,urine protein,and SCr in group B were lower than those of groups A and C,and the BUN level in group B was higher than that of groups A and C,the levels of ESR,urine protein,SCr and BUN in group A were higher than those in group C,with statistically significant differences(P<0.05).The levels of total protein(TP),albumin(ALB),prealbumin(PA),and hemoglobin(Hb)after treatment in the three groups were higher than those before treatment,the levels of TP,ALB,PA and Hb in group B were higher than those in groups A and C,with statistically significant differences(P<0.05).There was no statistical significance in the total incidence of adverse reactions among the three groups(P>0.05).Conclusion The effect of high-flux hemodialysis in the treatment of chronic renal failure and uremia is significantly better than that of con
作者
杨波
YANG Bo(Dialysis Room,Xincheng Hospital,Liaoyang Central Hospital,Liaoning Province,Liaoyang111000,China)
出处
《中国当代医药》
CAS
2022年第11期24-28,共5页
China Modern Medicine
