摘要
目的比较表柔比星、吉西他滨膀胱灌注化疗在浅表性膀胱尿路上皮癌患者中的应用效果。方法选择2018年8月至2019年9月本院收诊的106例浅表性膀胱尿路上皮癌患者作为研究对象,采用抽签法将其分为对照组和观察组,各53例。两组均接受经尿道电切术治疗,对照组术后给予表柔比星膀胱灌注化疗,观察组术后给予吉西他滨膀胱灌注化疗。比较两组的复发情况、肿瘤标志物水平、免疫功能指标、不良反应发生情况及生活质量。结果观察组的复发率低于对照组(P<0.05)。治疗后,两组的YKL-40、VEGF、DKK1、CK19、CA199水平均较治疗前降低(P<0.05);治疗后,两组的YKL-40、VEGF、DKK1、CK19、CA199水平比较,差异无统计学意义(P>0.05)。治疗后,两组的CD4^(+)、CD4^(+)/CD8^(+)、NK细胞均较治疗前降低,CD8^(+)均较治疗前升高(P<0.05);治疗后,两组的CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、NK细胞比较,差异无统计学意义(P>0.05)。观察组的不良反应总发生率低于对照组(P<0.05)。治疗后,两组的社会功能、认知功能、身体状态、情绪状态、家庭作用评分均较治疗前升高,且观察组高于对照组(P<0.05)。结论表柔比星、吉西他滨膀胱灌注化疗在浅表性膀胱尿路上皮癌患者中的应用效果较好,其均可降低肿瘤标志物水平,且对免疫功能指标的影响相当,但吉西他滨的安全性更高,复发率更低。
Objective To compare the application effects of intravesical instillation chemotherapy with epirubicin and gemcitabine in patients with superficial bladder urothelial carcinoma.Methods A total of 106 patients with superficial bladder urothelial carcinoma treated in our hospital from August 2018 to September 2019 were selected as the research objects.The patients were divided into control group and observation group by lottery,with 53 cases in each group.Both groups received transurethral resection treatment,the control group was given intravesical instillation chemotherapy with epirubicin after operation,and the observation group was given intravesical instillation chemotherapy with gemcitabine after operation.The recurrence situation,tumor markers levels,immune function indexes,occurrence of adverse reactions and quality of life were compared between the two groups.Results The recurrence rate of the observation group was lower than that of the control group(P<0.05).After treatment,the levels of YKL-40,VEGF,DKK1,CK19 and CA199 in the two groups were lower than those before treatment(P<0.05);after treatment,there were no significant differences in the levels of YKL-40,VEGF,DKK1,CK19 and CA199 between the two groups(P>0.05).After treatment,CD4^(+),CD4^(+)/CD8^(+)and NK cells in the two groups were lower than those before treatment,and CD8^(+)was higher than that before treatment(P<0.05);after treatment,there were no significant differences in CD4^(+),CD8^(+),CD4^(+)/CD8^(+)and NK cells between the two groups(P>0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).After treatment,the scores of social function,cognitive function,physical state,emotional state and family function in the two groups were higher than those before treatment,and those in the observation group were higher than the control group(P<0.05).Conclusion Intravesical instillation chemotherapy with epirubicin and gemcitabine applied in patients with superficial bladder urothelial car
作者
张治国
王玉
ZHANG Zhiguo;WANG Yu(Gem Flower Xi'an Changqing Staff Hospital,Xi'an 710201,China)
出处
《临床医学研究与实践》
2022年第16期66-70,共5页
Clinical Research and Practice
关键词
表柔比星
吉西他滨
膀胱灌注化疗
浅表性膀胱尿路上皮癌
肿瘤标志物
免疫功能
epirubicin
gemcitabine
intravesical instillation chemotherapy
superficial bladder urothelial carcinoma
tumor marker
immune function
